ASCC3 Antibody
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中文名稱：ASCC3兔多克隆抗體
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貨號：CSB-PA002198ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA002198ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA002198ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA002198ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ASCC3 Polyclonal antibody
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Uniprot No.：
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基因名：ASCC3
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別名：Activating signal cointegrator 1 complex subunit 3 antibody; ASC-1 complex subunit p200 antibody; ASC-1 complex subunit p200-KD subunit antibody; ASC1p200 antibody; ascc3 antibody; ATP binding 1 antibody; B630009I04Rik antibody; dJ121G13.4 antibody; DJ467N11.1 antibody; HELC1_HUMAN antibody; HELIC1 antibody; Helicase antibody; helicase; ATP binding 1 antibody; p200 antibody; RNA helicase family antibody; RNAH antibody; RP1-121G13.4 antibody; Trip4 complex subunit p200 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Activating signal cointegrator 1 complex subunit 3 protein (1-111AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes, as part of the ribosome quality control trigger (RQT) complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation.
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基因功能參考文獻：
- UV exposure results in spatial restriction of transcription and slower elongation, with the result that only the promoter-proximal 20-25 kb are efficiently transcribed; these events underlie a switch to expression of short mRNA isoforms and preferential use of alternative last exons in a number of genes, including ASCC3. PMID: 28215706
- ASCC3 Gene Polymorphism was associated with Chronic Hepatitis B. PMID: 26536629
- Silencing of ASCC3 resulted in upregulation of multiple antiviral interferon-stimulated genes, which correlated with inhibition of infection of several positive-strand RNA viruses. PMID: 23781071
- DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184
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亞細胞定位：Nucleus. Nucleus speckle. Cytoplasm, cytosol.
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蛋白家族：Helicase family
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組織特異性：Ubiquitous.
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數據庫鏈接：
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