ASCC1 Antibody
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中文名稱：ASCC1兔多克隆抗體
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貨號：CSB-PA305079
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA305079(ASCC1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA305079(ASCC1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：ASCC1
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別名：Activating signal cointegrator 1 complex subunit 1 antibody; ASC-1 complex subunit p50 antibody; ASC1 complex subunit p50 antibody; ASC1p50 antibody; ASCC1 antibody; ASCC1_HUMAN antibody; CGI 18 antibody; RP11-150D20.4 antibody; Trip4 complex subunit p50 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human ASCC1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction.
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基因功能參考文獻：
- Our patient was also found to have a homozygous frameshift variant (c.157dupG, p.Glu53Glyfs*19) in ASCC1 , thereby representing the second known case. This confirms ASCC1 involvement in a severe neuromuscular disease lying within the spinal muscular atrophy or primary muscle disease spectra PMID: 28218388
- ASCC1 inhibits NF-kappaB activation and a truncated and inactive variant of ASCC1 is associated with a more severe disease, which could have clinical value for assessing the progression and prognosis of Rheumatoid Arthritis. PMID: 26503956
- Three major genes, MSR1, ASCC1, and CTHRC1 were associated with Barrett esophagus/esophageal adenocarcinoma PMID: 21791690
- Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and ASC-1. PMID: 19074642
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相關疾?。?/div>Barrett esophagus (BE); Spinal muscular atrophy with congenital bone fractures 2 (SMABF2)亞細胞定位：Nucleus. Nucleus speckle.組織特異性：Ubiquitous.數據庫鏈接：
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