ASB9 Antibody
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中文名稱：ASB9兔多克隆抗體
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貨號：CSB-PA002195GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ASB9
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別名：ASB9 antibody; Ankyrin repeat and SOCS box protein 9 antibody; ASB-9 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Human ASB9
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
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基因功能參考文獻：
- Model of ASB9 in complex with its substrate, creatine kinase, reveals a mechanism for dynamic ubiquitin transfer. PMID: 27396830
- Molecular docking yielded a structural model consistent with all of the data that suggested the N-terminal residues of ASB9(1-252) may lie in one CK active site. This model was corroborated by enzymatic activity assays and mutational analysis. PMID: 25654263
- ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 N-terminal domain. PMID: 23837592
- His103 and Phe107 in hASB9-2 are essential for binding to CKB. PMID: 22418839
- The results of the present study suggest that ASB9 is a useful prognostic marker for colorectal cancer PMID: 20878058
- ASB9 interacts with the creatine kinase system and negatively regulates cell growth. PMID: 20302626
- The splice variant of hASB9, hASB9-2 protein, was cloned, overexpressed, and crystallized and the data showed that the cubic hASB9-2 crystal belongs to space group P4(3)32 with unit-cell parameters. PMID: 18680464
- The purified ASB9-2 protein, the splice variant of ASB9 with only one ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution. PMID: 19275750
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亞細胞定位：Mitochondrion.
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蛋白家族：Ankyrin SOCS box (ASB) family
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組織特異性：Predominantly expressed in testis, kidney, and liver.
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數據庫鏈接：
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