ARRDC1 Antibody

說明書

中文名稱：

ARRDC1兔多克隆抗體
貨號：

CSB-PA000933
規格：

￥1090
圖片：
Western Blot analysis of Jurkat cells using Arrdc1 Polyclonal Antibody

Western Blot analysis of AD293 cells using Arrdc1 Polyclonal Antibody
其他：

產品詳情

Uniprot No.：

Q8N5I2
基因名：

ARRDC1
別名：

ARRD1_HUMAN antibody; ARRDC 1 antibody; ARRDC1 antibody; Arrestin domain containing 1 antibody; Arrestin domain containing protein 1 antibody; Arrestin domain-containing protein 1 antibody; MGC40555 antibody; OTTHUMP00000022707 antibody; OTTHUMP00000022709 antibody; RP11-48C7.5 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Arrdc1.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway.
基因功能參考文獻：
1. The authors show that WWP1 changes the ubiquitination status of ARRDC1, suggesting that the arrestins may provide a platform for ubiquitination in PPXY-dependent budding. PMID: 21191027
亞細胞定位：

Cell membrane.
蛋白家族：

Arrestin family
數據庫鏈接：

HGNC: 28633

KEGG: hsa:92714

STRING: 9606.ENSP00000360475

UniGene: Hs.12999

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