ARL2BP Antibody
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中文名稱：ARL2BP兔多克隆抗體
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貨號：CSB-PA002081GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：ARL2BP
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別名：ADP ribosylation factor like 2 binding protein antibody; ADP-ribosylation factor-like protein 2-binding protein antibody; AR2BP_HUMAN antibody; Arf like 2 binding protein BART1 antibody; ARF-like 2-binding protein antibody; ARL2 binding protein antibody; Arl2bp antibody; ARL2BP protein antibody; BART antibody; BART1 antibody; Binder of ARF2 protein 1 antibody; Binder of Arl Two antibody; Binder of Arl2 antibody; Retinitis pigmentosa 66 (autosomal recessive) antibody; RP66 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human ARL2BP
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.
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基因功能參考文獻：
- This study identified two homozygous variants in ARL2BP as a rare cause of autosomal recessive retinitis pigmentosa. Further studies are required to define the underlying disease mechanism causing retinal degeneration as a result of mutations in ARL2BP and any phenotype-genotype correlation associated with residual levels of the wild-type transcript. PMID: 30210231
- Subsequent analysis of 844 index cases did not reveal further pathogenic chances in ARL2BP indicating that mutations in ARL2B are a rare cause of arRCD (about 0.1%) in a large cohort of French patients. PMID: 27790702
- Alteration of EBV encoded miR-BART1 expression results in an increase in migration and invasion of nasopharyngeal carcinoma in vitro and causes metastasis in vivo. EBV-miR-BART1 directly targets the cellular tumour suppressor PTEN. PMID: 26135619
- EBV also downregulates two immediate early genes by miR-BART20-5p. PMID: 24899173
- Mutations in ARL2BP cause autosomal-recessive retinitis pigmentosa. PMID: 23849777
- EBV-miR-BART1 could influence the expression of metabolism-associated genes and might be involved in cancer metabolism in nasopharyngeal carcinoma PMID: 23685147
- Our results imply that BART regulates actin-cytoskeleton rearrangements at membrane ruffles through modulation of the activity of Rac1, which, in turn, inhibits pancreatic cancer cell invasion. PMID: 22745590
- These results imply that BART contributes to regulating PKCalpha activity through binding to ANX7, thereby affecting the invasiveness of pancreatic cancer cells. PMID: 22532868
- We identify a subset of BART miRNAs that are restricted to Latency III in normal infection but are up regulated in tumors that express Latency I and II. PMID: 21901094
- Our results imply that BART increases active RhoA by inhibiting ARL2 function, which in turn inhibits invasiveness of cancer cells. PMID: 21833473
- Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. PMID: 19368893
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相關疾病：Retinitis pigmentosa with or without situs inversus (RPSI)
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亞細胞定位：Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body.
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蛋白家族：ARL2BP family
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組織特異性：Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
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數據庫鏈接：
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