ARHGEF11 Antibody

中文名稱：

ARHGEF11兔多克隆抗體
貨號：

CSB-PA002043LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA002043LA01HU diluted at 1:500 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ARHGEF11 Polyclonal antibody
Uniprot No.：

O15085
基因名：

ARHGEF11
別名：

ARHGB_HUMAN antibody; ARHGEF 11 antibody; ARHGEF11 antibody; DKFZp667F1223 antibody; Glutamate transporter EAAT4 associated protein 48 antibody; GTRAP 48 antibody; GTRAP48 antibody; KIAA0380 antibody; OTTHUMP00000038716 antibody; OTTHUMP00000038717 antibody; PDZ RHOGEF antibody; PDZ-RhoGEF antibody; Rho guanine exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor 11 antibody; RhoA specific guanine nucleotide exchange factor antibody; RhoGEF glutamate transport modulator antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Rho guanine nucleotide exchange factor 11 protein (1221-1318AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ARHGEF11 Antibody (CSB-PA002043LA01HU)，的標記方式是Non-conjugated。對于ARHGEF11 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA002043LB01HU	ARHGEF11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002043LC01HU	ARHGEF11 Antibody, FITC conjugated
Biotin	CSB-PA002043LD01HU	ARHGEF11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
基因功能參考文獻：
1. PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF. PMID: 27765920
2. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
3. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. PMID: 26627240
4. Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia PMID: 25319871
5. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
6. analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF PMID: 21816819
7. The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population. PMID: 21210224
8. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein. PMID: 12183458
9. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho PMID: 14625312
10. ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia PMID: 14684465
11. PDZ-RhoGEF interacts with the actin cytoskeleton PMID: 14742719
12. This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer. PMID: 16691626
13. Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. PMID: 17287471
14. Sequence variation in this gene may influence susceptibility to and risk of type II diabetes. PMID: 17369523
15. PDZRhoGEF (PRG), mediates RhoA-dependent responses and determines their spatial distribution in differentiated HL60 cells. PMID: 18086913
16. R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. PMID: 18231709
17. the autoinhibition of PRG is caused largely by an interaction of a short negatively charged sequence motif, immediately upstream of the DH-domain. PMID: 19460155
18. The actin-binding domain of PDZ-RhoGEF, located between amino acids 561 and 585, directly binds to F-actin in vitro and could influence actin structure in a manner independent of its ability to activate RhoA. PMID: 19618964
19. PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375
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亞細胞定位：

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 14580

OMIM: 605708

KEGG: hsa:9826

STRING: 9606.ENSP00000357177

UniGene: Hs.516954

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