ARHGEF1 Antibody

說明書

中文名稱：

ARHGEF1兔多克隆抗體
貨號：

CSB-PA123263
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA123263(ARHGEF1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA123263(ARHGEF1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

Q92888
基因名：

ARHGEF1
別名：

115 kD protein antibody; 115 kDa guanine nucleotide exchange factor antibody; ARHG1_HUMAN antibody; ARHGEF 1 antibody; ARHGEF1 antibody; GEF 1 antibody; GEF1 antibody; LBCL 2 antibody; LBCL2 antibody; LSC antibody; Lsc homolog antibody; p115 RhoGEF antibody; p115-RhoGEF antibody; p115RhoGEF antibody; Rho guanine nucleotide exchange factor (GEF) 1 antibody; Rho guanine nucleotide exchange factor 1 antibody; Sub1.5 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human ARHGEF1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
基因功能參考文獻：
1. Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 = Rho guanine nucleotide exchange factor 1; RAC1 = Rac family small GTPase 1; CCL2 = C-C motif chemokine ligand 2) PMID: 28655771
2. Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif. PMID: 28179147
3. We have reported here for the first time a reduced activity of both Rac1 and Cdc42 in human pheochromocytoma resection as well as tumor-associated expression changes of FARP1, ARHGEF1, and ARHGAP36 PMID: 26911374
4. contactin-1 displayed the ability to phosphorylate the RhoA activator p115 RhoGEF PMID: 25916117
5. The novel role for p115RhoGEF in regulation of epithelial plasticity is dependent on Rho-DRF signaling module. PMID: 24465552
6. Regulated localization is sufficient for hormonal control of regulator of G protein signaling homology Rho guanine nucleotide exchange factors (RH-RhoGEFs). PMID: 24855647
7. Modification of p115RhoGEF at Serine(330) regulates its RhoGEF activity. PMID: 23816534
8. The action of DOCK7 in vivo may involve the coordinated integration of Cdc42/Rac1 signaling in the context of the membrane recruitment of a DOCK7 guanine nucleotide exchange factor (GEF) complex. PMID: 23718289
9. High GEF1 expression is associated with metastasis of pancreatic cancer. PMID: 23070684
10. Activation of p115-RhoGEF requires direct association of Galpha13 and the Dbl homology domain. PMID: 22661716
11. Upon beta(2)AR activation, both betaArrestin2 and p115RhoGEF translocate to the plasma membrane, with concomitant activation of RhoA and formation of focal adhesions and stress fibers. PMID: 22500016
12. Thromboxane receptor signaling is required for fibronectin-induced matrix metalloproteinase 9 production by human and murine macrophages and is attenuated by the Arhgef1 molecule. PMID: 22086927
13. Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG). PMID: 21454492
14. The linker region connecting the N-terminal RGS-homology domain and the Dbl homology domain inhibits the intrinsic guanine nucleotide exchange activity of p115. PMID: 21064165
15. ARHGEF1 is involed in hypertension by controlling its molecular mechanisms. PMID: 20619149
16. coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation PMID: 12372594
17. rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13) PMID: 12525488
18. CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression PMID: 12748184
19. data demonstrate a pathway of Rho activation involving protein kinase c alpha-dependent phosphorylation of p115Rho guanine exchange factor PMID: 12754211
20. Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors. PMID: 15143072
21. Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. PMID: 15735747
22. analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway PMID: 17493936
23. A pronounced and rapid translocation of p115-RhoGEF from the cytosol to the plasma membrane was observed upon activation of several G(12/13)-coupled receptors in a cell type-independent fashion. PMID: 18320579
24. Data show that microtubules in neighboring cells reorient and target p115 RhoGEF to sites where dying cells are squeezed out of the epithelial sheet. PMID: 19720875
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亞細胞定位：

Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation.
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 681

OMIM: 601855

KEGG: hsa:9138

STRING: 9606.ENSP00000337261

UniGene: Hs.631550

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