ARHGAP10 Antibody

說(shuō)明書

中文名稱：

ARHGAP10兔多克隆抗體
貨號(hào)：

CSB-PA002012LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002012LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA002012LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ARHGAP10 Polyclonal antibody
Uniprot No.：

A1A4S6
基因名：

ARHGAP10
別名：

Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Rho GTPase-activating protein 10 protein (542-744AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，ARHGAP10 Antibody (CSB-PA002012LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ARHGAP10 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA002012LB01HU	ARHGAP10 Antibody, HRP conjugated	ELISA
FITC	CSB-PA002012LC01HU	ARHGAP10 Antibody, FITC conjugated
Biotin	CSB-PA002012LD01HU	ARHGAP10 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
基因功能參考文獻(xiàn)：
1. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
2. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
3. PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851
亞細(xì)胞定位：

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
組織特異性：

High levels of expression in heart and skeletal muscle.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 26099

OMIM: 609746

KEGG: hsa:79658

STRING: 9606.ENSP00000336923

UniGene: Hs.368631

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