APPBP2 Antibody

說明書

產品詳情

Uniprot No.：

Q92624
基因名：

APPBP2
別名：

amyloid beta precursor protein (cytoplasmic tail) binding protein 2 antibody; Amyloid beta precursor protein-binding protein 2 antibody; Amyloid protein binding protein 2 antibody; Amyloid protein-binding protein 2 antibody; APBP2_HUMAN antibody; APP BP2 antibody; APP-BP2 antibody; Appbp2 antibody; PAT1 antibody; Protein interacting with APP tail 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human APPBP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation. The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron. May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface.
基因功能參考文獻：
1. It facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunits. PMID: 25194880
2. Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides. PMID: 12915535
亞細胞定位：

Nucleus. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein.
數據庫鏈接：

HGNC: 622

OMIM: 605324

KEGG: hsa:10513

STRING: 9606.ENSP00000083182

UniGene: Hs.84084

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