APBB1IP Antibody
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中文名稱：APBB1IP兔多克隆抗體
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貨號：CSB-PA030130
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規格：￥1090
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圖片：
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Western Blot analysis of A549 cells using RIAM Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：APBB1IP antibody; PREL1 antibody; RARP1 antibody; RIAMAmyloid beta A4 precursor protein-binding family B member 1-interacting protein antibody; APBB1-interacting protein 1 antibody; Proline-rich EVH1 ligand 1 antibody; PREL-1 antibody; Proline-rich protein 73 antibody; Rap1-GTP-interacting adapter molecule antibody; RIAM antibody; Retinoic acid-responsive proline-rich protein 1 antibody; RARP-1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human RIAM.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
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基因功能參考文獻：
- Authors provide an overview of the structure and interactions of RIAM and discuss the implications of RIAM functions in innate and adaptive immunity and cancer. [Review] PMID: 28831022
- Disruption of the RIAM/lamellipodin-integrin-talin complex markedly impairs cell migration. PMID: 26419705
- RIAM is a critical component of the phagocytosis machinery downstream of Rap1 and mediates its function by recruiting talin to the phagocytic complement receptors. PMID: 23420480
- integrin-triggered, RIAM-dependent MEK activation represents a key feedback event required for efficient focal adhesion disassembly. PMID: 22946047
- RIAM was recruited to the lymphocyte plasma membrane through its Ras association and pleckstrin homology domains, both of which were required for lymphocyte adhesion. PMID: 23045549
- RIAM might contribute to the dissemination of melanoma cells. PMID: 21454517
- by regulating the localization of PLC-gamma1, RIAM plays a central role in TCR signaling and the transcription of target genes. PMID: 19952372
- all-trans-retinoic acid-inducible RARP1 selectively affects signal transduction and may contribute to myeloid and megakaryocytic differentiation.(RARP1) PMID: 14530287
- Data pinpoint PREL1 as the first direct link between Ras signalling and cytoskeletal remodelling via Ena/VASP proteins during cell migration and spreading. PMID: 15642358
- a minimized 50-residue Rap-RIAM module containing the talin binding site of RIAM joined to the membrane-targeting sequence of Rap1A. This minimized Rap-RIAM module was sufficient to target talin to the plasma membrane and to mediate integrin activation PMID: 19098287
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亞細胞定位：Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, focal adhesion. Cytoplasm, cytoskeleton.
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蛋白家族：MRL family
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組織特異性：Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
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數據庫鏈接：
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