APBA2 Antibody

說明書

中文名稱：

APBA2兔多克隆抗體
貨號：

CSB-PA001887GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q99767
基因名：

APBA2
別名：

Adapter protein X11beta antibody; Amyloid beta A4 precursor protein-binding family A member 2 antibody; APBA2 antibody; APBA2_HUMAN antibody; D15S1518E antibody; HsT16821 antibody; LIN 10 antibody; MGC:14091 antibody; MGC99508 antibody; Mint 2 antibody; Mint-2 antibody; MINT2 antibody; Neuron-specific X11L protein antibody; Neuronal Munc18-1-interacting protein 2 antibody; Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody; X11 beta antibody; X11 like protein antibody; X11l antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Human APBA2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta.
基因功能參考文獻：
1. These results support the hypothesis that APBA2 gene expression in different areas of Alzheimer's patient's brains. PMID: 28164769
2. Aberrant MINT2 methylation in body fluids may predict peritoneal micrometastasis for gastric cancer (GC) patients, which is a potential poor prognostic factor in GC. PMID: 24385013
3. a significant difference was shown for APBA2 gene expression of peripheral lymphocytes between Chinese Han Tourette syndrome (TS) group and healthy controls idicating the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects PMID: 23076970
4. Amyloid beta A4 precursor protein-binding family A member 2 contains a potent neuronal promoter whose activity may be regulated by DNA methylation and glucocorticoid receptor [alpha], paired box protein 5. PMID: 22222501
5. The co-occurrence of two nonsynonymous mutations in both affected siblings in a single family, each transmitted from a different unaffected parent, suggest a role for APBA2 mutations in rare individuals with ASD. PMID: 20029827
6. APBA2 were genes activated in early endometrial endometrioid carcinoma (stages I-II). PMID: 20015385
7. X11beta-mediated reduction in cerebral Abeta is associated with cognition and long-term potentiation in Alzheimer's disease APPswe transgenic mice. PMID: 19744962
8. Interaction of transcriptional coactivators with Mint1 or Mint2 prevents nuclear localization and transactivation of the transduction network mediated by amyloid precursor protein. PMID: 20016085
9. The APBA2 gene has been found to map to a more telomeric location in chromosome 15q13 than previously found, and is partially duplicated within the broader region located approximately 5 Mb distal to the intact locus. PMID: 12720574
10. hXB51 isoforms regulate Abeta generation differently, either enhancing it by modifying the association of X11L with APP or suppressing it in an X11L-independent manner PMID: 12780348
11. This protein, which is a member of the mammalian LIN-10 protein family and a possible regulator of Abeta production, elevated APP and APLP2 phosphorylation PMID: 14970211
12. Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. PMID: 17989066
13. Phosphorylation of amino acids Ser236 and Ser238 in the X11L regulatory region are critical for increasing association of X11L and amyloid beta-protein precursor and are conserved in X11, a neuronal X11 family protein, but not in non-neuronal X11L2. PMID: 19222704
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組織特異性：

Brain.
數據庫鏈接：

HGNC: 579

OMIM: 602712

KEGG: hsa:321

STRING: 9606.ENSP00000453144

UniGene: Hs.618112

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