ANKRD26 Antibody

說明書

中文名稱：

ANKRD26兔多克隆抗體
貨號：

CSB-PA008262
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9UPS8
基因名：

ANKRD26
別名：

Ankrd26 antibody; Ankyrin repeat domain 26 antibody; Ankyrin repeat domain-containing protein 26 antibody; Ankyrin repeat domaincontaining protein 26 antibody; ANR26_HUMAN antibody; bA145E8.1 antibody; KIAA1074 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human ANKRD26.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior.
基因功能參考文獻：
1. in a cohort of patients with suspected familial thrombocytopenia, the c.-140C>G mutation seems to be the most frequent ANKRD26 mutation. PMID: 28277066
2. Two cases with mutant ANKRD26 highlight that patients with thrombocytopenia 2 are at risk of being misdiagnosed with myelodysplastic syndrome and receiving undue myelosuppressive treatments. Because dysmegakaryopoiesis is a feature also of other forms of inherited thrombocytopenia, a genetic disorder must always be considered when a patient presents with isolated thrombocytopenia and dysmegakaryopoiesis. PMID: 28976612
3. investigation of one patient with the c.3G>A showed that mutation was associated with strong ANKRD26 overexpression in vivo, which is the proposed mechanism for predisposition to AML in THC2 patients PMID: 28100250
4. The findings of lifelong thrombocytopenia with mild/absent bleeding, family history of thrombocytopenia with normal platelet size and myeloid neoplasms should raise the suspicion of ANKRD26 mutated thrombocytopenia. PMID: 27123948
5. Molecular analysis identified a mutation located in the promoter of the ankyrin repeat domain 26 (ANKRD26) gene, c.-127A>T in normocytic thrombocytopenia. PMID: 27108925
6. thrombocytopenia with 5'UTR ANKRD26 gene mutation must be considered in case of a constitutional isolated thrombocytopenia, with a low bleeding tendency, associated with autosomal dominant transmission and normal platelet volume. PMID: 25902755
7. WASP, RUNX1, and ANKRD26 genes are important for normal TPO signaling and the network underlying thrombopoiesis. PMID: 26175287
8. The study supports the association of ANKRD26 mutations with thrombocytopenia 2 and a predisposition to myeloid malignancies. PMID: 24628296
9. ANKRD26 regulatory region mutations induce MAPK hyperactivation in familial thrombocytopenia PMID: 24430186
10. the missense mutations may paly a role in the pathogenesis of Autosomal-dominant nonsyndromic thrombocytopenia-2 PMID: 23869080
11. Studies indicate that ANKRD26-RT is an insidious form of inherited thrombocytopenias that exposes patients to a low risk of bleeding but predisposes them to hematologic myeloid malignancies. PMID: 24030261
12. Ubiquitin/proteasome-rich particulate cytoplasmic structures are a characteristic feature of ANKRD26-related thrombocytopenia platelets and megakaryocytes. PMID: 23223974
13. The ANKRD26-related thrombocytopenia has to be taken into consideration in the differential diagnosis of isolated thrombocytopenias. PMID: 21467542
14. mutations in the 5' UTR of ANKRD26 are implicated in thrombocytopenia 2. PMID: 21211618
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相關(guān)疾病：

Thrombocytopenia 2 (THC2)
數(shù)據(jù)庫鏈接：

HGNC: 29186

OMIM: 188000

KEGG: hsa:22852

STRING: 9606.ENSP00000365255

UniGene: Hs.361041

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