ANKRD2 Antibody, Biotin conjugated
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中文名稱：ANKRD2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA875635LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ANKRD2 Polyclonal antibody
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Uniprot No.：
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基因名：ANKRD2
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別名：ANKRD2 antibody; ARPPAnkyrin repeat domain-containing protein 2 antibody; Skeletal muscle ankyrin repeat protein antibody; hArpp antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Ankyrin repeat domain-containing protein 2 protein (1-210AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress.
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基因功能參考文獻：
- The results set the stage for investigation of the specific functions and interactions of the Ankrd2 isoforms in healthy and diseased human striated muscles. PMID: 27393496
- The Ankrd2 was found to be expressed in both the cytoplasm and nucleus, independently from maturation status of cardiomyocytes. PMID: 25585647
- Report structure activity relationships for ANKRD2. PMID: 25125175
- Ankrd2 as a potent repressor of inflammatory responses through direct interaction with the NF-kappaB repressor subunit p50. PMID: 24434510
- The orthologs of ANKRD2 in mouse and rat, which are also titin binding proteins, are stretch-response genes associated with slow muscle function and these proteins are part of a separate mechanotransduction system to the one that regulates muscle mass. PMID: 15677738
- Although analyzed in a limited number of patients, there is a considerable body of evidence that MARP proteins could be suitable candidates for prognostic and diagnostic biomarkers. PMID: 22185618
- Ankrd2 is a potent regulator in muscle cells affecting a multitude of pathways and processes PMID: 22016770
- Ankrd2 is a novel Akt2 specific substrate and regulates myogenic differentiation PMID: 21737686
- These findings suggest that type-specific expression patterns of ARPP and CARP are altered in skeletal muscles of amyotrophic lateral sclerosis. PMID: 12679596
- Ankrd2 may be involved in sensing stress signals and linking these to muscle gene regulation PMID: 15136035
- Arpp is a novel skeletal muscle-specific marker, which is useful for differential diagnosis of rhabdomyosarcoma PMID: 16021567
- ARPP was localized in mitochondria and nuclei in both the normal distal renal tubule and oncocytoma but not in chromophobe renal cell carcinomas. PMID: 17206105
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亞細胞定位：Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
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組織特異性：Mostly expressed in skeletal and cardiac muscles. Found in slow fibers. Also expressed in kidney, but to a lower extent (at protein level).
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數據庫鏈接：
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