ANKRD11 Antibody

文獻引用 (1) 說明書

中文名稱：

ANKRD11兔多克隆抗體
貨號：

CSB-PA757769LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA757769LA01HU diluted at 1:700 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

Immunofluorescence staining of U251 cell with CSB-PA757769LA01HU at 1:450, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of U251 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of A431 cell with CSB-PA757769LA01HU at 1:450, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of A431 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ANKRD11 Polyclonal antibody
Uniprot No.：

Q6UB99
基因名：

ANKRD11
別名：

ANKRD11 antibody; ANCO1Ankyrin repeat domain-containing protein 11 antibody; Ankyrin repeat-containing cofactor 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Ankyrin repeat domain-containing protein 11 protein (1002-1276AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ANKRD11 Antibody (CSB-PA757769LA01HU)，的標記方式是Non-conjugated。對于ANKRD11 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA757769LB01HU	ANKRD11 Antibody, HRP conjugated	ELISA
FITC	CSB-PA757769LC01HU	ANKRD11 Antibody, FITC conjugated
Biotin	CSB-PA757769LD01HU	ANKRD11 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:800
IF	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

SERPINA3-ANKRD11-HDAC3 pathway induced aromatase inhibitor resistance in breast cancer can be reversed by HDAC3 inhibition J Zhou,Communications biology,2023

產品評價

靶點詳情

功能：

Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis.
基因功能參考文獻：
1. ANKRD11 variants cause variable clinical features associated with KBG syndrome and Coffin-Siris-like syndrome. PMID: 28250421
2. exome sequencing identified a novel de novo heterozygous single base pair duplication (c.6015dupA) in ANKRD11, which is predicted to lead to a premature stop codon and loss of function in ANKRD11, thereby implicating it as contributing to the molecular diagnosis of KBG syndrome. PMID: 27900361
3. Here we report a large series of 39 patients with KBG syndrome; these patients harbored ANKRD11 mutations (20 cases) or deletions (19 cases). All the mutations were found by targeted molecular analysis on patients with clinical features suggestive of KBG. PMID: 27605097
4. Twelve novel cases of haploinsufficiency for ANKRD11-flanking genes make the difference between KBG and 16q24.3 microdeletion syndromes. PMID: 28422132
5. These findings point out the importance of screening ANKRD11 in young CdLS patients who were found to be negative for mutations in the five known CdLS genes. PMID: 25652421
6. Further delineation of the KBG syndrome phenotype on large patients cohort caused by ANKRD11 aberrations has been presented. PMID: 25424714
7. we conclude that severe short stature, intellectual disability, and macrodontia are the main characteristics in KBG syndrome related to ANKRD11 mutation PMID: 25464108
8. ANKRD11 C-terminus plays an important role in regulating the abundance of the protein, and a disturbance of the protein abundance due to the mutations leads to KBG syndrome. PMID: 25413698
9. AIB1, AIB1-delta4 and ANCO1 are important determinants of endocrine and growth factor responsiveness in breast cancer. PMID: 24678732
10. The complete neurological and psychiatric features observed in two patients with KBG syndrome due to ANKRD11 mutations, are reported. PMID: 23184435
11. Partial deletion of ANKRD11 results in the KBG phenotype distinct from the 16q24.3 microdeletion syndrome. PMID: 23494856
12. aberrant DNA methylation of three CpGs in a 19 bp region within the ANKRD11 promoter may be responsible for its down-regulation in breast cancer. PMID: 22538187
13. Mutations in ANKRD11 cause KBG syndrome and outline a fundamental role of ANKRD11 in craniofacial, dental, skeletal, and central nervous system development and function. PMID: 21782149
14. ANKRD11 is a candidate gene for autism and variable cognitive impairment in the novel 16q24.3 microdeletion syndrome. PMID: 19920853
15. Together, these results indicate that the transcriptional potential of ANCO-1 may be modulated by a combination of repression and activation signals. PMID: 17521611
16. ANKRD11 has a role as a p53 coactivator and may be involved in a regulatory feedback loop with p53 PMID: 18840648
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相關疾病：

KBG syndrome (KBGS)
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 21316

OMIM: 148050

KEGG: hsa:29123

STRING: 9606.ENSP00000301030

UniGene: Hs.335003

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