ANKRD1 Antibody

說明書

中文名稱：

ANKRD1兔多克隆抗體
貨號：

CSB-PA001217
規格：

￥1090
圖片：
Western Blot analysis of COLO205 cells using CARP Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q15327
基因名：

ANKRD1
別名：

ALRP antibody; ANKR1_HUMAN antibody; ANKRD 1 antibody; ANKRD1 antibody; Ankyrin repeat domain 1 (cardiac muscle) antibody; Ankyrin repeat domain containing protein 1 antibody; Ankyrin repeat domain-containing protein 1 antibody; bA320F15.2 antibody; C 193 antibody; C193 antibody; Cardiac ankyrin repeat protein antibody; CARP antibody; CVARP antibody; Cytokine inducible nuclear protein antibody; Cytokine-inducible gene C-193 protein antibody; Cytokine-inducible nuclear protein antibody; HA1A2 antibody; Liver ankyrin repeat domain 1 antibody; MCARP antibody; OTTHUMP00000020084 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the C-terminal region of Human CARP.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
基因功能參考文獻：
1. review of CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases [review] PMID: 27143260
2. These data suggest that hepatitis C virus coopts ANKRD1 for its own propagation and up-regulation of ANKRD1 may contribute to hepatitis C virus-mediated liver pathogenesis. PMID: 26860204
3. To the Ankrd1, it is not responsive to the cardiotoxic drug Doxorubicin, suggesting that different mechanisms govern their expression in cardiac cells. PMID: 25585647
4. The association of ANKRD1 with antiapoptotic response suggests its role as myocyte survival factor during late stage heart disease, warranting further studies on ANKRD1 during end-stage heart failure. PMID: 25961010
5. Report structure activity relationships for ANKRD1. PMID: 25125175
6. ANKRD1 has a significant role in the regulation of apoptosis in human ovarian cancer cells PMID: 24531715
7. Augmented CARP expression may be a common molecular event in failing hearts regardless of cardiomyopathic aetiology. PMID: 19359327
8. Report impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue. PMID: 23572067
9. the 26S proteasome is the dominant regulator of Ankrd1/CARP degradation, and that Ankrd1/CARP half-life is significantly longer in cardiomyocytes (h) than endothelial cells (min). PMID: 22892129
10. Ankrd1 and desmin may play important roles in airway smooth muscle cell homeostasis. PMID: 22085644
11. CARP and its regulator calpain 3 appear to occupy a central position in the important cell fate-governing NF-kappaB pathway in skeletal muscle PMID: 20860623
12. p53 operates as an upstream effector of Ankrd1/CARP, by up regulating the proximal ANKRD1 promoter PMID: 20599664
13. On the basis of genetic and functional analysis of CARP mutations, ANKRD1 has been identified as a new gene associated with dilated cardiomyopathy, accounting for approximately 2% of the 231 cases studied. PMID: 19525294
14. CD45 lateral mobility is regulated by the spectrin-ankyrin cytoskeleton of T cells PMID: 20164196
15. Cardiac ankyrin repeat protein, a negative regulator of cardiac gene expression, is augmented in human heart failure. PMID: 12054667
16. CARP expression is observed by in situ hybridization in endothelial cells lining human atherosclerotic plaques, whereas lesion macrophages are devoid of CARP; it is induced by activin A in cultured intimal smooth muscle cells. PMID: 12524226
17. endogenous ANKRD1 and calsequestrin are co-enriched in piglet cardiac Purkinje cells PMID: 15698842
18. CARP interacts with itself and desmin. CARP, ankrd2, and DARP contain potential coiled-coil dimerization motifs within their unique aminoterminal domains that mediate the formation of homo-dimers. PMID: 16450059
19. CARP was expressed in renal podocytes at a high level in 10 of 13 cases of crescentic glomerulonephritis, 7 of 19 cases of diabetic nephropathy, and 12 of 20 cases of lupus nephritis. PMID: 17239933
20. cloned both translocation breakpoints and mapped the ANKRD1 gene, encoding a cardiac transcriptional regulator, 130 kb proximally to the breakpoint on chromosome 10, in total anomalous pulmonary venous return, a congenital heart defect PMID: 18273862
21. Our results indicate that CARP is a sensitive and specific marker for rhabdomyosarcoma and that it will be useful for the differential diagnosis of rhabdomyosarcoma. PMID: 18656235
22. We suggest that CDH1 cytoplasmic immunolocalization as a result of increased IGF-II levels identifies those nonmuscle invasive presentations most likely to recur PMID: 18980987
23. Data show that ANKRD1 is a short-lived protein whose levels are tightly regulated by the 26S proteasome. PMID: 19589340
24. ANKRD1 is a novel DCM gene, with mutations present in 1.9% of DCM patients. The ANKRD1 mutations may cause DCM PMID: 19608030
25. CARP abnormalities may be involved in the pathogenesis of HCM. PMID: 19608031
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相關疾病：

Total anomalous pulmonary venous return (TAPVR)
亞細胞定位：

Nucleus.
組織特異性：

Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
數據庫鏈接：

HGNC: 15819

OMIM: 106700

KEGG: hsa:27063

STRING: 9606.ENSP00000360762

UniGene: Hs.448589

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