AMOTL2 Antibody
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中文名稱：AMOTL2兔多克隆抗體
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貨號：CSB-PA940902
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA940902(AMOTL2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：AMOTL2
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別名：AMOL2_HUMAN antibody; Amotl2 antibody; angiomotin like 2 antibody; Angiomotin-like protein 2 antibody; KIAA0989 antibody; LCCP antibody; Leman coiled coil protein antibody; Leman coiled-coil protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human AMOTL2
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
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基因功能參考文獻：
- these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP and AKT in liver size control and cancer prevention PMID: 28368415
- AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients. PMID: 25080976
- These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process. PMID: 23525008
- AMOTL2 interacts with TAZ and modulates transcriptional activity of TAZ. PMID: 23911299
- Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells PMID: 21937427
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亞細(xì)胞定位：Recycling endosome.
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蛋白家族：Angiomotin family
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數(shù)據(jù)庫鏈接：
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