AMER1 Antibody
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中文名稱：AMER1兔多克隆抗體
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貨號：CSB-PA918886
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA918886(AMER1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA918886(AMER1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：AMER1 antibody; FAM123B antibody; WTXAPC membrane recruitment protein 1 antibody; Amer1 antibody; Protein FAM123B antibody; Wilms tumor gene on the X chromosome protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthetic peptide of Human AMER1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
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基因功能參考文獻：
- A novel heterozygous frameshift mutation in AMER1 was identified in a patient with osteopathia striata with cranial sclerosis. PMID: 28893644
- Losses of AMER1 by other mechanisms apart from mutations. PMID: 26071483
- A nonsense mutation (c.1045C>T, p.Glu349*) in the WTX gene. PMID: 24459086
- WTX inactivation occurs in a wider variety of tumor types than previously appreciated and point to shared pathogenic mechanisms between a subset of pediatric malignancies. PMID: 24249259
- Data indicate that osteopathia striata congenita with cranial sclerosis (OSCS) iscaused by germline deletions of in the X-linked gene WTX (FAM123B, AMER1). PMID: 22670894
- Two novel WTX mutations underscore the unpredictability of male survival in osteopathia striata with cranial sclerosis. PMID: 20950377
- Stat3 inhibits WTX expression through up-regulation of micro RNA-370 in Wilms tumor. PMID: 23333300
- Osteopathia striata with cranial sclerosis or Horan-Beighton syndrome is a rare X-linked dominant inherited bone dysplasia. Genetic analysis allowed the identification of maternally transmitted heterozygous nonsense c.1057C>T (p.R353X) WTX mutation. PMID: 22716240
- WTX mutations occur early in Wilms' tumor development, but at a low proportion. There was no evidence that WTX is the main cause of Wilms' tumor. PMID: 22800892
- WTX modulates p53 function, in part through regulation of its activator CBP/p300. PMID: 22285752
- WTX and NRF2 compete for binding to KEAP1, and thus loss of WTX leads to rapid ubiquitination and degradation of NRF2 and a reduced response to cytotoxic insult. PMID: 22215675
- Amer1 exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the plasma membrane. PMID: 21498506
- WTX mutations can arise both early and late in Wilms tumour development PMID: 20679664
- When gene expression changes mediated by wild-type WTX were compared with those affected by mutant WTX, WTX565 had a 55% overlap in differentially regulated genes, whereas WTX358 regulated only two genes affected by wild-type WTX. PMID: 20956941
- Mutations in the WTX-gene are associated with high-grade microsatellite instable colorectal cancers. PMID: 20696052
- inactivation of WTX appears to be a late event in tumorigenesis of nephroblastoma in a subgroup of nephroblastomas PMID: 19757195
- All investigated families diagnosed with Osteopathia striata with cranial sclerosis had WTX gene defects. PMID: 20209645
- WTX, is inactivated in approximately one-third of Wilms tumors; it is inactivated by a monoallelic "single-hit" event targeting the single X chromosome in tumors from males and the active X chromosome in tumors from females PMID: 17204608
- findings show that WTX, a protein encoded by a gene mutated in Wilms tumors, forms a complex with beta-catenin, AXIN1, beta-TrCP2 and APC; data provide a possible mechanistic explanation for the tumor suppressor activity of WTX PMID: 17510365
- Deletion of the WTX gene is associated with Wilms' tumor with a balanced translocation t(X;18) PMID: 17620295
- These data indicate that AMER1 controls the subcellular distribution of APC between membrane- and microtubule-associated pools, and might thereby regulate APC-dependent cellular morphogenesis, cell migration and cell-cell adhesion. PMID: 17925383
- Gene has a tumor suppressor function in Wilms tumors, and is involved in beta-catenin destruction. PMID: 18021721
- WT1 and WTX mutations occur with similar frequency, that they partially overlap in Wilms tumors, and that mutations in WT1, WTX, and CTNNB1 underlie the genetic basis of about one-third of Wilms tumors PMID: 18311776
- Functional inactivation of the WTX gene is not a frequent event in Wilms' tumors. PMID: 18391980
- there was not any evidence of WTX mutation in the 143 acute leukemia patients PMID: 18452086
- WTX is rarely mutated in acute myeloid leukemia PMID: 18460646
- Data indicate that WTX mutation is rare in colorectal, gastric, and hepatocellular carcinomas. PMID: 18720004
- The observed phenotypic discordance dependent upon whether a mutation is germline or occurs somatically suggests the existence of temporal or spatial constraints on the action of WTX during tumorigenesis. PMID: 19079258
- Mutations in WTX gene is associated with Wilms tumor. PMID: 19137020
- WTX binds WT1 and enhances WT1-mediated transcription, suggesting a role for WTX in nuclear pathways implicated in the transcriptional regulation of cellular differentiation programs PMID: 19416806
- WTX inactivation is associated with Wilms tumors PMID: 19760609
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相關疾?。?/div>Osteopathia striata with cranial sclerosis (OSCS)亞細胞定位：Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Translocates to the cell membrane following binding to PtdIns(4,5)P2.蛋白家族：Amer family組織特異性：Detected in fetal and adult kidney, brain and spleen.數據庫鏈接：
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