ALOX15B Antibody

說明書

中文名稱：

ALOX15B兔多克隆抗體
貨號：

CSB-PA001622GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O15296
基因名：

ALOX15B
別名：

15 Lipoxygenase 2 antibody; 15 LO 2 antibody; 15 LOX 2 antibody; 15-lipoxygenase 2 antibody; 15-LOX-2 antibody; 15-LOX-B antibody; Alox15b antibody; Arachidonate 15 lipoxygenase second type antibody; Arachidonate 15 lipoxygenase type II antibody; Arachidonate 15-lipoxygenase B antibody; Arachidonate 15-lipoxygenase type II antibody; LX15B_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ALOX15B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist. Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates. Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively downregulate the immune response and have anti-aggregation properties with platelets. In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids. Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.; Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.
基因功能參考文獻：
1. Ca(2+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT domain. PMID: 28809482
2. 15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop. PMID: 27435673
3. these results demonstrate the strict regiospecificity of h15-LOX-2 that circumscribes its role in transcellular synthesis. PMID: 27145229
4. This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2. PMID: 26918937
5. The ALOX15B gene may be associated with coronary artery disease. PMID: 24373925
6. Hpoxia-induced pulmonary vascular remodeling is associated with increased levels of 15-LO-2. PMID: 25895668
7. ALOX15 rs11568070 polymorphisms did not discriminate for the disease or its severity. PMID: 24975552
8. 15-LOX2 expression inhibits Myc-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia. PMID: 24732589
9. activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin generation PMID: 24533104
10. Positive feedback-loop of TERT and 15-lipoxygenase-2 promotes pulmonary hypertension. PMID: 24376652
11. Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain. PMID: 24497644
12. ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4, LPS and hypoxia. PMID: 22980500
13. The C2-domain is not essential for catalytic activity and does hardly impact reaction specificity. PMID: 21951814
14. Tumor-associated macrophages isolated from RCC tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid. PMID: 21900394
15. In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms. PMID: 21316676
16. Results from this study suggest a 125-bp region (-157 to -33) is critical for the 15-LOX-2 promoter activity in prostate epithelial cells and cancer cells PMID: 20428779
17. a negative cell cycle regulator in normal prostate epithelial cells, but not present in prostatic neoplasms PMID: 11839751
18. 15-LOX-2 expression is lost in esophageal cancers and the induction of 15-LOX-2 can inhibit cancer cell proliferation PMID: 12659684
19. 15-LOX2 and its splice variants suppress prostate tumor development PMID: 12704195
20. Sp1 and Sp3 proteins play a physiologically important role in positively and negatively regulating the 15-LOX2 gene expression, respectively. PMID: 15247906
21. feedback mechanisms may contribute to the loss of 15-LOX-2 pathway components, which coincide with an increase in PPAR-gamma in many epithelial cancers PMID: 15799828
22. Crosstalk mechanisms exist between the 15-LOX-2 gene and peroxisome proliferator-activated receptor gamma (PPARgamma) to counterbalance expression and help explain the inverse relationship of these genes in normal prostate versus prostate cancer cells. PMID: 16682954
23. Loss of heterozygosity on 17p13 and down-regulation of ALOX15B can be used to discriminate adrenal cortex neoplasms from adrenocortical adenoma. PMID: 18156936
24. 13-(S)-hydroxyoctadecadienoic acid (13-HODE) is docked to solvent-exposed histidines of a 15-hLOX-2 homology model and found to bind well with histidine627, suggesting a potential location for the allosteric site. PMID: 19645454
25. Expression of 8S-LOX and 15S-LOX-2 suppresses CRD-BP/IMP-1 expression, resulting in inhibition of human prostate carcinoma PC-3 cell proliferation. PMID: 19661680
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亞細胞定位：

[Isoform A]: Nucleus.; Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell junction, focal adhesion.
蛋白家族：

Lipoxygenase family
組織特異性：

Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
數據庫鏈接：

HGNC: 434

OMIM: 603697

KEGG: hsa:247

STRING: 9606.ENSP00000369530

UniGene: Hs.111256

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