ALKBH8 Antibody
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中文名稱：ALKBH8兔多克隆抗體
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貨號：CSB-PA842644ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA842644ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ALKBH8 Polyclonal antibody
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Uniprot No.：
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基因名：ALKBH8
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別名：4930562C03Rik antibody; 8030431D03Rik antibody; 9430088N01Rik antibody; ABH8 antibody; alkB alkylation repair homolog 8 (E. coli) antibody; alkB alkylation repair homolog 8 antibody; AlkB homologue 8 antibody; ALKB8_HUMAN antibody; ALKBH8 antibody; Alkylated DNA repair protein alkB homolog 8 antibody; FLJ38204 antibody; MGC10235 antibody; OTTHUMP00000211286 antibody; OTTHUMP00000211287 antibody; Probable alpha-ketoglutarate-dependent dioxygenase ABH8 antibody; RGD1304687 antibody; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 antibody; tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Alkylated DNA repair protein alkB homolog 8 protein (1-230AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.
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基因功能參考文獻：
- findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer PMID: 27329810
- Many eukaryotic tRNAs contain the wobble modification 5-methoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8. PMID: 21285950
- The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described. PMID: 20123966
- Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival. PMID: 20308323
- Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1-dependent ROS signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK/p38/gammaH2AX-mediated cell death by silencing of ALKBH8. PMID: 19293182
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亞細胞定位：Cytoplasm. Nucleus.
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蛋白家族：AlkB family
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組織特異性：Widely expressed, with highest expression in spleen, followed by pancreas and lung.
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數據庫鏈接：
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