ALDOB Antibody

說明書

中文名稱：

ALDOB兔多克隆抗體
貨號：

CSB-PA001586GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P05062
基因名：

ALDOB
別名：

ALDB antibody; ALDO B antibody; ALDO2 antibody; ALDOB antibody; ALDOB_HUMAN antibody; Aldolase 2 antibody; Aldolase B antibody; Aldolase B fructose bisphosphate antibody; Aldolase2 antibody; AldolaseB antibody; EC 4.1.2.13 antibody; Fructose bisphosphate aldolase B antibody; Fructose-bisphosphate aldolase B antibody; Liver type aldolase antibody; Liver-type aldolase antibody; MS1077 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ALDOB
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Silencing Aldolase B activated epithelial markers and repressed mesenchymal markers, indicating inactivation of Aldolase B may lead to inhibition of epithelial-mesenchymal transition PMID: 28558381
2. The downregulation of ALDOB could indicate a poor prognosis for HCC patients, and therefore, ALDOB might be considered a prognostic biomarker for HCC, especially at the early stage. PMID: 26376879
3. Single nucleotide polymorphisms in ALDOB, MAP3K1, and MEF2C are associated with cataract. PMID: 25352737
4. both of exogenous and endogenous ALDOB proteins bind to hepatitis B surface antigen and colocalize in the cytoplasm in vitro and inhibit apoptosis of cisplatin-induced HepG2 cells. PMID: 25072145
5. Efficient inhibition of aldolase B can prevent high glucose-induced overproduction of methylglyoxal and related cellular dysfunction in endothelial cells. PMID: 22911800
6. Aldolase B with the A149P substitution has activity that is <100-fold that of the wild type. PMID: 21166391
7. These novel mutations in ALDOB represent 2% of alleles in American HFI (hereditary fructose intolerance) patients, with IVS1+1G>C representing a significantly higher allele frequency (6%) among HFI patients of Hispanic and African-American ethnicity. PMID: 20882353
8. This is the first report of six unrelated patients sharing the same ALDOB deletion, thus indicating a founder effect for this allele. PMID: 20848650
9. Biochemical study of defective aldolase B enzymes is key to revealing the molecular basis of the disease and providing a stronger basis for improved treatment and diagnosis PMID: 20162364
10. Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance. PMID: 12417303
11. The enzyme's structure and function is investigated as a function of temperature.The implications of these structural alterations are discussed with regard to the HFI disease PMID: 12464284
12. expression of three (Beclin 1, RbAp48 and Pir51) were increased and one (aldolase b) was decreased in liver tumor tissues PMID: 14966907
13. six new aldolase B mutations in seven unrelated hereditary fructose intolerant (HFI) Italian patients PMID: 15532022
14. Based on these data and after correction for less common and private ALDOB mutations, hereditary fructose intolerance (HFI) prevalence in central Europe is estimated to be 1:26,100 (95% confidence interval 1: 12,600-79,000). PMID: 15880727
15. Reverse-hybridization assay tested for an accurate and robust screening tool to identify common ALDOB mutations. PMID: 17292585
16. Usefulness of ALDOB mutation in screening for diagnosis of hereditary fructose intolerance. PMID: 17457694
17. there is an important role for physical association between aldolase and the A, B and E subunits of V-ATPase in the regulation of the proton pump PMID: 17576770
18. Hereditary fructose intolerance with the mutation c.479_482 del AACA PMID: 17955389
19. Sixteen different mutations of the aldolase B (ALDOB) gene were identified in hereditary fructose intolerance patients. PMID: 18541450
20. The five gene transcripts (aldolase B, elafin, MST-1, simNIPhom and SLC6A14) were changed in patients with ulcerative colitis, and were related to the disease activity. PMID: 18700007
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相關疾病：

Hereditary fructose intolerance (HFI)
亞細胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.
蛋白家族：

Class I fructose-bisphosphate aldolase family
數據庫鏈接：

HGNC: 417

OMIM: 229600

KEGG: hsa:229

STRING: 9606.ENSP00000363988

UniGene: Hs.530274

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