ALDH1B1 Antibody

說明書

中文名稱：

ALDH1B1兔多克隆抗體
貨號：

CSB-PA001568ESR1HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: Aldehyde dehydrogenase X, mitochondrial antibody at 4μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Rat brain tissue
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57 kDa
Observed band size: 57 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001568ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001568ESR1HU at dilution of 1:100
其他：

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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ALDH1B1 Polyclonal antibody
Uniprot No.：

P30837
基因名：

ALDH1B1
別名：

Acetaldehyde dehydrogenase 5 antibody; AL1B1_HUMAN antibody; Aldehyde dehydrogenase 1 family; member B1 antibody; Aldehyde dehydrogenase 1B1 antibody; Aldehyde dehydrogenase 5 antibody; Aldehyde dehydrogenase family 1 member B1 antibody; Aldehyde dehydrogenase X antibody; Aldehyde dehydrogenase X mitochondrial antibody; ALDH class 2 antibody; Aldh1b1 antibody; ALDH5 antibody; ALDHX antibody; MGC2230 antibody; Mitochondrial aldehyde dehydrogenase X antibody; mitochondrial antibody; OTTHUMP00000021399 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Rat
免疫原：

Recombinant Human Aldehyde dehydrogenase X, mitochondrial protein (278-517AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
基因功能參考文獻(xiàn)：
1. These results suggest that ALDH1B1 is a novel human colorectal cancer biomarker PMID: 28881356
2. The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. PMID: 28594837
3. ALDH1B1 is expressed at very high levels in human pancreatic cancer, and it contributes to proliferation in these tumor cells. PMID: 26566217
4. High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. PMID: 26366059
5. Data show that ALDH1B1 may promote colon cancer tumorigenesis by modulating the Wnt/beta-catenin, Notch and PI3K/Akt signaling pathways. PMID: 25950950
6. ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. PMID: 25413692
7. ALDH1B1 SNPs play a role in shaping the alcohol drinking patterns among the Inuit in Greenland. PMID: 25311581
8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
9. ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer. PMID: 21216231
10. An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin PMID: 20955166
11. a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity. PMID: 20205700
12. ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample PMID: 18782342
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亞細(xì)胞定位：

Mitochondrion matrix.
蛋白家族：

Aldehyde dehydrogenase family
組織特異性：

Liver, testis and to a lesser extent in brain.
數(shù)據(jù)庫鏈接：

HGNC: 407

OMIM: 100670

KEGG: hsa:219

STRING: 9606.ENSP00000366927

UniGene: Hs.436219

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