Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期:
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
基因功能參考文獻:
AKAP3 correlates with triple negative status and disease free survival in breast cancer. PMID: 26458542
study reports the isolation of AKAP3 and CTp11 Cancer/testis antigens from hepatocellular carcinoma patient sera PMID: 22941507
CABYR variants form a complex not only with the scaffolding protein AKAP3 but also with another RII-like domain-containing protein in the sperm fibrous sheath. PMID: 21240291
evidence of tyrosine phosphorylation during sperm capacitation PMID: 12509440
In Cox multivariate analysis, AKAP3 mRNA expression was found to be a significant predictor of both overall and progression-free survival in patients with poorly differentiated tumors. PMID: 14618620
AKAP-3 demonstrates tumor-restricted expression and appears to be associated with worse overall survival. PMID: 16005946
AKAP3 is a novel target for protein S-nitrosylation in spermatozoa. PMID: 17683036
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亞細胞定位:
Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.