AIFM3 Antibody
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中文名稱：AIFM3兔多克隆抗體
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貨號：CSB-PA001494GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：AIFM3
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別名：AIFL antibody; Aifm3 antibody; AIFM3_HUMAN antibody; Apoptosis inducing factor 3 antibody; Apoptosis inducing factor like antibody; Apoptosis inducing factor like protein antibody; Apoptosis inducing factor; mitochondrion associated antibody; Apoptosis-inducing factor 3 antibody; Apoptosis-inducing factor-like protein antibody; FLJ30473 antibody; FLJ45137 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human AIFM3
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
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基因功能參考文獻：
- Upregulated expression of AIFM3 is associated with cholangiocarcinoma. PMID: 27473083
- The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age. PMID: 22550867
- AIFM3 is a direct target of miR-210 in human hepatoma cells. PMID: 22387901
- AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain. PMID: 15764604
- AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function. PMID: 16001080
- H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events PMID: 19166416
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亞細胞定位：Mitochondrion. Note=Does not translocate to the nucleus upon induction of apoptosis.
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蛋白家族：FAD-dependent oxidoreductase family
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組織特異性：Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
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數據庫鏈接：
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