AGR3 Antibody

中文名稱：

AGR3兔多克隆抗體
貨號：

CSB-PA848404LA01HU
規格：

￥440
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AGR3 Polyclonal antibody
Uniprot No.：

Q8TD06
基因名：

AGR3
別名：

AG-3 antibody; AG3 antibody; Agr3 antibody; AGR3_HUMAN antibody; Anterior gradient 3; xenopus; homolog of antibody; Anterior gradient homolog 3 antibody; Anterior gradient homolog 3 (Xenopus laevis) antibody; anterior gradient protein 3 antibody; Anterior gradient protein 3 homolog antibody; BCMP11 antibody; Breast cancer membrane protein 11 antibody; Gm888 antibody; hAG 3 antibody; hAG-3 antibody; HAG3 antibody; OTTHUMP00000158512 antibody; PDIA18 antibody; Protein disulfide isomerase family A member 18 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Anterior gradient protein 3 protein (22-166AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AGR3 Antibody (CSB-PA848404LA01HU)，的標記方式是Non-conjugated。對于AGR3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA848404LB01HU	AGR3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA848404LC01HU	AGR3 Antibody, FITC conjugated
Biotin	CSB-PA848404LD01HU	AGR3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells.
基因功能參考文獻：
1. Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC. PMID: 29620196
2. transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A PMID: 25868611
3. Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer. PMID: 25875093
4. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. PMID: 25751668
5. Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues. PMID: 25666661
6. AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma PMID: 24747240
7. AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression. PMID: 22361111
8. AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. PMID: 21451362
9. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein] PMID: 12592373
10. specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members PMID: 15935701
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亞細胞定位：

Endoplasmic reticulum.
蛋白家族：

AGR family
組織特異性：

Expressed in the lung, in the ciliated cells of the airway epithelium. Expression increased with differentiation of airway epithelial cells. Not detected in the mucous cells. Expressed in ciliated cells in the oviduct. Also detected in stomach, colon, pro
數據庫鏈接：

HGNC: 24167

OMIM: 609482

KEGG: hsa:155465

STRING: 9606.ENSP00000308606

UniGene: Hs.100686

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