AGAP1 Antibody
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中文名稱：AGAP1兔多克隆抗體
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貨號(hào)：CSB-PA780863
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA780863(AGAP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human liver cancer tissue, hela cells, mouse lung tissue, Primary antibody: CSB-PA780863(AGAP1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：AGAP 1 antibody; AGAP-1 antibody; Agap1 antibody; AGAP1_HUMAN antibody; Arf GAP with GTP binding proteinlike ANK repeat and PH domains 1 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with GTPase domain ankyrin repeat and PH domain 1 antibody; Centaurin gamma 2 antibody; Centaurin-gamma-2 antibody; CENTG2 antibody; Cnt-g2 antibody; GGAP 1 antibody; GGAP1 antibody; GTP binding and GTPase activating protein 1 antibody; GTP-binding and GTPase-activating protein 1 antibody; KIAA1099 antibody; MGC71657 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthetic peptide of Human AGAP1
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:25-1:100 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點(diǎn)詳情
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功能：GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)-dependent trafficking of proteins in the endosomal-lysosomal system.
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基因功能參考文獻(xiàn)：
- The effect of AGAP1 Knockdown could be rescued by FLAG-AGAP1, but not by an AGAP1 mutant that did not bind Kif2A efficiently, ArfGAP1-HA or Kif2A-GFP. The results support the hypothesis that the Kif2A.AGAP1 complex contributes to control of cytoskeleton remodeling involved in cell movement. PMID: 27531749
- GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. PMID: 22453919
- overexpression inhibited formation of platelet-derived growth factor-induced ruffles and also induced loss of actin stress fibers PMID: 12388557
- AGAP1 is a novel binding partner of nitric oxide-sensitive guanylyl cyclase PMID: 15381706
- CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism. PMID: 15892143
- The AGAP1 has been found to associate with the adaptor protein complex AP-3 and regulate the function of AP-3 endosomes. PMID: 16079295
- AGAP1 is unique among the AZAPs in its specificity for Arf1, and this activity is dependent on its NH(2)-terminal GTPase-like domain. AGAP1 induce reciprocal activation of Arf6. PMID: 18003747
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亞細(xì)胞定位：Cytoplasm. Note=Associates with the endocytic compartment.
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蛋白家族：Centaurin gamma-like family
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組織特異性：Widely expressed.
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數(shù)據(jù)庫(kù)鏈接：
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