AFG1L Antibody

中文名稱：

AFG1L兔多克隆抗體
貨號：

CSB-PA819895LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, Rat kidney tissue
All lanes: AFG1L antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 55 kDa
Observed band size: 55 kDa

IHC image of CSB-PA819895LA01HU diluted at 1:600 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA819895LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA819895LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AFG1L Polyclonal antibody
Uniprot No.：

Q8WV93
基因名：

AFG1L
別名：

AFG1 antibody; ATPase family gene 1 homolog antibody; CG8520 gene product antibody; lace1 antibody; LACE1_HUMAN antibody; Lactation elevated protein 1 antibody; Lactivation elevated 1 antibody; Protein AFG1 homolog antibody
宿主：

Rabbit
反應種屬：

Human, Rat
免疫原：

Recombinant Human AFG1-like ATPase protein (14-313AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AFG1L Antibody (CSB-PA819895LA01HU)，的標記方式是Non-conjugated。對于AFG1L Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA819895LB01HU	AFG1L Antibody, HRP conjugated	ELISA
FITC	CSB-PA819895LC01HU	AFG1L Antibody, FITC conjugated
Biotin	CSB-PA819895LD01HU	AFG1L Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:500-1:1000
IF	1:200-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress.
基因功能參考文獻：
1. Increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis. PMID: 27323408
2. This study establishes LACE1 as a novel factor with a crucial role in mitochondrial protein homeostasis. PMID: 26759378
3. association between bipolar disorder and two SNPs in the gene LACE1 PMID: 20872768
4. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
5. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
8. Observational study of genetic testing. (HuGE Navigator) PMID: 18237552
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亞細胞定位：

Mitochondrion membrane.
蛋白家族：

AFG1 ATPase family
數據庫鏈接：

HGNC: 16411

OMIM: 617469

KEGG: hsa:246269

STRING: 9606.ENSP00000357973

UniGene: Hs.259666

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