AFF2 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AFF2 Polyclonal antibody
Uniprot No.：

P51816
基因名：

AFF2
別名：

AF4/FMR2 family member 2 antibody; AF4/FMR2 family, member 2 antibody; AFF2 antibody; AFF2_HUMAN antibody; FMR2 antibody; FMR2P antibody; Fragile X E mental retardation syndrome protein antibody; fragile X mental retardation 2 antibody; Fragile X mental retardation 2 protein antibody; fragile X mental retardation gene associated with FRAXE antibody; FRAXE antibody; mild or borderline mental retardation antibody; MRX2 antibody; OTTHUMP00000024204 antibody; OX19 antibody; Protein FMR-2 antibody; Protein Ox19 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human AF4/FMR2 family member 2 protein (575-705AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AFF2 Antibody (CSB-PA001413LA01HU)，的標記方式是Non-conjugated。對于AFF2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001413LB01HU	AFF2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001413LC01HU	AFF2 Antibody, FITC conjugated
Biotin	CSB-PA001413LD01HU	AFF2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
基因功能參考文獻：
1. Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia. PMID: 25256661
2. FMR2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of ID- and FRAXE-associated ID in particular. PMID: 23562910
3. 2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites. PMID: 22773736
4. A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X E in a small subset of patients. PMID: 22065534
5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300
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相關疾病：

Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE)
亞細胞定位：

Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles.
蛋白家族：

AF4 family
組織特異性：

Brain (most abundant in hippocampus and amygdala), placenta and lung.
數據庫鏈接：

HGNC: 3776

OMIM: 300806

KEGG: hsa:2334

STRING: 9606.ENSP00000359489

UniGene: Hs.496911

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