ADK Antibody

說明書

中文名稱：

ADK兔多克隆抗體
貨號：

CSB-PA247810
規格：

￥1090
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P55263
基因名：

ADK
別名：

2310026J05Rik antibody; 5033405D03Rik antibody; Adenosine 5''-phosphotransferase antibody; Adenosine kinase antibody; adk antibody; ADK_HUMAN antibody; AI255373 antibody; AI987814 antibody; AK antibody; MGC6593 antibody; OTTHUMP00000019864 antibody; OTTHUMP00000019865 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the N-terminal region of Human ADK.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
基因功能參考文獻：
1. The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID: 28789481
2. rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID: 26040919
3. The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID: 25575137
4. These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID: 24128682
5. Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID: 22092111
6. The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID: 21635241
7. The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID: 20881134
8. The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID: 20698827
9. Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID: 12820662
10. role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID: 18309031
11. adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID: 18600536
12. both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID: 18600545
13. This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID: 19635462
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相關疾病：

Hypermethioninemia due to adenosine kinase deficiency (HMAKD)
亞細胞定位：

[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.
蛋白家族：

Carbohydrate kinase PfkB family
組織特異性：

Widely expressed. Highest level in placenta, liver, muscle and kidney.
數據庫鏈接：

HGNC: 257

OMIM: 102750

KEGG: hsa:132

STRING: 9606.ENSP00000286621

UniGene: Hs.656586

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