ADD2 Antibody

說明書

中文名稱：

ADD2兔多克隆抗體
貨號：

CSB-PA436650
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA436650(ADD2 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

P35612
基因名：

ADD2
別名：

ADD 2 antibody; ADD2 antibody; ADDB antibody; ADDB_HUMAN antibody; Adducin 2 (beta) antibody; Adducin2 antibody; Beta adducin antibody; Beta-adducin antibody; Erythrocyte adducin subunit beta antibody; OTTHUMP00000203378 antibody; OTTHUMP00000203908 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Fusion protein of Human ADD2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:15-1:50

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
基因功能參考文獻：
1. betaadducin was demonstrated to have a critical role in neutrophil migration. PMID: 29901076
2. Aberrant DNA methylation of ADD2 could be potential screening markers of colorectal cancer. PMID: 27493446
3. Study evaluated effects of ADD genetic variability on cognitive functions in a sample of patients with schizophrenia, known to show a wide and heterogeneous neuropsychological deficit and found that ADD2 C1797T polymorphism showed diffuse effects on almost every cognitive domain. PMID: 26723519
4. ADD2 and NCX1 variants influence the risk and the clinical features of systemic lupus erythematosus and lupus nephritis. PMID: 26045217
5. Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin. PMID: 25425738
6. phosphorylation of beta-adducin by GSK3 promotes efficient neurite outgrowth in neurons. PMID: 21606488
7. there was significant heterogeneity between Slavic and Italian subjects in the phenotype-genotype relationships with beta-adducin PMID: 14553963
8. Expression of the hypertensive rat or human variant of adducin into normal renal epithelial cells recreates the hypertensive phenotype with higher Na+,K+-ATPase activity, mu2-subunit hyperphosphorylation, and impaired Na+,K+-ATPase endocytosis. PMID: 15528469
9. Polymorphisms in the ADD2 and ADD3 genes taken alone were not associated with blood pressure and renin activity PMID: 15716695
10. The very high levels of expression of ADD2 suggest that its promoter may be useful for directing erythroid-specific gene expression. PMID: 15963851
11. beta-adducin is a downstream target of and regulated by the PTN/RPTPbeta/zeta signaling pathway PMID: 16105548
12. Changes in intra-erythrocyte cations in ADD2 1797CC homozygous men might lead to osmotic fragility of erythrocytes, but to what extent they reflect systemic changes or are possibly involved in blood pressure regulation remains unknown. PMID: 17301826
13. hypertension candidate gene variation may influence BP responses to specific antihypertensive drug therapies and measurement of genetic variation may assist in identifying subgroups of hypertensive patients benefiting from antihypertensive drug therapies PMID: 17854487
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亞細胞定位：

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
蛋白家族：

Aldolase class II family, Adducin subfamily
組織特異性：

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.
數據庫鏈接：

HGNC: 244

OMIM: 102681

KEGG: hsa:119

STRING: 9606.ENSP00000264436

UniGene: Hs.188528

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