ADCY7 Antibody

說明書

中文名稱：

ADCY7兔多克隆抗體
貨號：

CSB-PA006812
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P51828
基因名：

ADCY7
別名：

ADCY7 antibody; KIAA0037Adenylate cyclase type 7 antibody; EC 4.6.1.1 antibody; ATP pyrophosphate-lyase 7 antibody; Adenylate cyclase type VII antibody; Adenylyl cyclase 7 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from the Internal region of Human A Cyclase VII.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
IF	1:200-1:1000
ELISA	1:5000

Protocols：

Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors. Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.
基因功能參考文獻：
1. We discovered a 0.6% frequency missense variant in ADCY7. PMID: 28067910
2. The stronger TNF-alpha responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 and ADCY9. PMID: 25959651
3. The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients. PMID: 26220344
4. evidence implicates ADCY7 in the modulation of mood regulatory neural mechanisms and, possibly, risk for and pathophysiology of depression. PMID: 22264442
5. we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women, and these markers are also associated with ADCY7 expression (messenger RNA) levels. PMID: 21481845
6. construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase PMID: 11665607
7. The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit, interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC. PMID: 15581358
8. Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice. PMID: 17135423
9. AC7 is a specific downstream effector of the G(12/13) pathway PMID: 18541530
10. soluble adenylyl cyclase is responsive to both CO(2) and bicarbonate ion PMID: 19008230
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Adenylyl cyclase class-4/guanylyl cyclase family
數(shù)據(jù)庫鏈接：

HGNC: 238

OMIM: 600385

KEGG: hsa:113

STRING: 9606.ENSP00000254235

UniGene: Hs.513578

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