ADAMTS2 Antibody

說明書

中文名稱：

ADAMTS2兔多克隆抗體
貨號：

CSB-PA801690
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA801690(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA801690(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and 293T cell, Primary antibody: CSB-PA801690(ADAMTS2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

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靶點詳情

產品詳情

Uniprot No.：

O95450
基因名：

ADAMTS2
別名：

A disintegrin and metalloproteinase with thrombospondin motifs 2 antibody; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2 antibody; ADAM metallopeptidase with thrombospondin type 1 motif 2 antibody; ADAM TS 2 antibody; ADAM TS2 antibody; ADAM-TS 2 antibody; ADAM-TS2 antibody; ADAMTS 3 antibody; ADAMTS-2 antibody; ADAMTS2 antibody; ATS2_HUMAN antibody; EC 3.4.24.14 antibody; EDS VIIB antibody; EDS VIIC antibody; hPCPNI antibody; NPI antibody; PC I NP antibody; PC I-NP antibody; PCINP antibody; PCPNI antibody; pNPI antibody; Procollagen I N proteinase antibody; Procollagen I N-proteinase antibody; Procollagen I/II amino propeptide processing enzyme antibody; Procollagen I/II amino propeptide-processing enzyme antibody; Procollagen N endopeptidase antibody; Procollagen N-endopeptidase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human ADAMTS2
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity.
基因功能參考文獻：
1. We identified three novel homozygous loss-of-function mutations (c.2927_2928delCT, p.(Pro976Argfs*42); c.669_670dupG, p.(Pro224Argfs*24); and c.2751-2A>T) and one compound heterozygous mutation (c.2T>C, p.? and c.884_887delTGAA, p.(Met295Thrfs26*)) in ADAMTS2 in five patients from four unrelated families PMID: 26765342
2. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review] PMID: 25863161
3. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
4. ADAMTS2 was significantly overexpressed in Fibrous dysplasia (FD) tissues, but rarely expressed in normal bone tissues, suggesting that ADAMTS2 could be a potential biomarker for FD PMID: 25674217
5. Pathway inhibition studies revealed that ADAMTS-2 upregulation by IL-6 was mediated by JNK pathway. PMID: 24752352
6. Data show that ADAMTS-2 is able to reduce proliferation of endothelial cells, and to induce their retraction and detachment from the substrate resulting in apoptosis. PMID: 20574651
7. Determination of the processing, activity and cleavage specificity of the bovine ADAMTS2 protein. PMID: 16046392
8. when conditioned media of TSP2-transfectants were added to cultures of bovine pulmonary microvascular endothelial cells (BPMEC), the BPMEC proliferation was significantly inhibited; suggesting that human TSP2 is a potential inhibitor of angiogenesis PMID: 11788898
9. Although exons 3-5 or 14-16 encode protein domains that have not been recognized as crucial for ADAMTS-2 activity, the aminoprocollagen processing was strongly impaired, providing evidence for the requirement of these domains for proper enzyme function PMID: 15373769
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相關疾?。?/div>
Ehlers-Danlos syndrome 7C (EDS7C)
亞細胞定位：

Secreted, extracellular space, extracellular matrix.
組織特異性：

Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
數據庫鏈接：

HGNC: 218

OMIM: 225410

KEGG: hsa:9509

STRING: 9606.ENSP00000251582

UniGene: Hs.23871

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