ADAMTS15 Antibody

中文名稱：

ADAMTS15兔多克隆抗體
貨號：

CSB-PA837445LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA837445LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ADAMTS15 Polyclonal antibody
Uniprot No.：

Q8TE58
基因名：

ADAMTS15
別名：

A disintegrin and metalloproteinase with thrombospondin motifs 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease reprolysin type with thrombospondin type 1 motif 15 preproprotein antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 antibody; A disintegrin like and metalloprotease with thrombospondin type 1 motif 15 preproprotein antibody; ADAM metallopeptidase with thrombospondin type 1 motif 15 antibody; ADAM TS 15 antibody; ADAM TS15 antibody; ADAM-TS 15 antibody; ADAM-TS15 antibody; ADAMTS 15 antibody; ADAMTS-15 antibody; ADAMTS15 antibody; ATS15_HUMAN antibody; MGC126403 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 15 protein (801-913AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ADAMTS15 Antibody (CSB-PA837445LA01HU)，的標記方式是Non-conjugated。對于ADAMTS15 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA837445LB01HU	ADAMTS15 Antibody, HRP conjugated	ELISA
FITC	CSB-PA837445LC01HU	ADAMTS15 Antibody, FITC conjugated
Biotin	CSB-PA837445LD01HU	ADAMTS15 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration.
基因功能參考文獻：
1. ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas. PMID: 28323982
2. ADAMTS15 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
3. ADAMTS15 is a candidate gene for intracranial aneurysms PMID: 25649796
4. ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4. PMID: 25099234
5. Versican processing by ADAMTS5 and ADAMTS15 contribute to muscle fiber formation. PMID: 23233679
6. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene PMID: 20590445
7. ADAMTS8 and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma PMID: 16152618
8. ADAMTS15 may be target of inactivating mutations in human cancer. PMID: 19458070
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亞細胞定位：

Secreted, extracellular space, extracellular matrix. Cell surface.
組織特異性：

Expressed in fetal liver and kidney, but not in any of the adult tissues examined.
數據庫鏈接：

HGNC: 16305

OMIM: 607509

KEGG: hsa:170689

STRING: 9606.ENSP00000299164

UniGene: Hs.534221

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