ADAM19 Antibody
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中文名稱：ADAM19兔多克隆抗體
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貨號：CSB-PA880929ESR1HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA880929ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880929ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ADAM19 Polyclonal antibody
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Uniprot No.：
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基因名：ADAM19
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別名：ADAM19 antibody; MLTNB antibody; FKSG34Disintegrin and metalloproteinase domain-containing protein 19 antibody; ADAM 19 antibody; EC 3.4.24.- antibody; Meltrin-beta antibody; Metalloprotease and disintegrin dendritic antigen marker antibody; MADDAM antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 protein (203-460AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.
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基因功能參考文獻：
- 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease. PMID: 27078193
- ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. PMID: 26912236
- these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells PMID: 26823772
- miR-30c inhibited colon cancer cells via targeting ADAM19. PMID: 25799050
- four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease. PMID: 25114068
- ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
- MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 PMID: 25475731
- ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls. PMID: 23429442
- Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
- Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma. PMID: 21239057
- These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2. PMID: 20460109
- ADAM19 correlates with the progress and prognosis of endometrial carcinoma. PMID: 18458692
- ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation. PMID: 19727588
- activation by furin via one of two consecutive recognition sites PMID: 12006600
- investigation of proteolytic activity PMID: 12393862
- yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19 PMID: 12463424
- A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues. PMID: 15242783
- ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene. PMID: 15896713
- ADAM19 may have a modulatory role in the dysfunctional renal allograft state PMID: 16827870
- results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein PMID: 17112471
- we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer. PMID: 18714391
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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組織特異性：Expressed in many normal organ tissues and several cancer cell lines.
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