ACSS2 Antibody

文獻引用 (1) 說明書

中文名稱：

ACSS2兔多克隆抗體
貨號：

CSB-PA873629ESR2HU
規格：

￥440
圖片：
Western blot
All lanes: ACSS2antibody at 2.14μg/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse kidney tissue
Lane 3: U87 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 79, 81 kDa
Observed band size: 79 kDa

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA873629ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ACSS2 Polyclonal antibody
Uniprot No.：

Q9NR19
基因名：

ACSS2
別名：

ACAS2 antibody; AceCS antibody; Acetate CoA ligase antibody; Acetate thiokinase antibody; Acetate--CoA ligase antibody; Acetyl CoA synthetase antibody; Acetyl Coenzyme A synthetase 2 (ADP forming) antibody; Acetyl coenzyme A synthetase cytoplasmic antibody; Acetyl-CoA synthetase antibody; Acetyl-coenzyme A synthetase antibody; ACS antibody; ACSA antibody; ACSA_HUMAN antibody; ACSS2 antibody; Acyl activating enzyme antibody; Acyl CoA synthetase short chain family member 2 antibody; Acyl-activating enzyme antibody; Acyl-CoA synthetase short-chain family member 2 antibody; Cytoplasmic acetyl coenzyme A synthetase antibody; cytoplasmic antibody; MYH7B antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Acetyl-coenzyme A synthetase, cytoplasmic protein (462-701AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease N Chen,Biochemical pharmacology,2023

產品評價

靶點詳情

功能：

Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity.
基因功能參考文獻：
1. High ACSS2 expression is associated with renal cell carcinoma. PMID: 29503142
2. A novel biologic role for ACSS2 in recycling of nuclear acetate for histone acetylation to promote lysosomal and autophagy-related gene expression and counteract nutritional stress, highlighting the importance of ACSS2 in maintaining autophagy and lysosome-mediated cellular energy homeostasis during tumor development. PMID: 28820290
3. ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection. PMID: 28167750
4. ACSS2 is an important factor for promoting RCC development and is essential for cell migration and invasion, which it promotes by increasing the expression of LAMP1. PMID: 29444517
5. these findings suggest that downregulation of acetyl-CoA synthetase-2 expression is a metabolic hallmark of tumor progression and aggressive behavior in colorectal carcinoma. PMID: 27713423
6. Exogenous acetate augments Acss2/HIF-2 dependent cancer growth and metastasis in cell culture and mouse models PMID: 29281714
7. The nuclear-cytosolic acetyl-CoA synthetase 2 recaptures acetate released from histone deacetylation for recycling by histone acetyltransferases. PMID: 28099844
8. In a Honduran population, the odds of having nonsyndromic cleft lip/palate (NSCLP) among carriers of the ACSS2 variant was 4.0 with a carrier frequency of 7.1% in unrelated affected and 1.9% in unrelated unaffected individuals. In a Colombian population, the odds of having NSCLP among carriers of the ACSS2 variant was 2.6 with a carrier frequency of 10.0% in unrelated affected and 4.1% in unrelated unaffected individuals. PMID: 28543373
9. In the nucleus, ACSS2 binds to transcription factor EB and translocates to lysosomal and autophagy gene promoter regions, where ACSS2 incorporates acetate generated from histone acetylation turnover to locally produce acetyl-CoA for histone H3 acetylation in these regions and promote lysosomal biogenesis, autophagy, cell survival, and brain tumorigenesis. PMID: 28552616
10. ACSS2 is essential for glucose-independent acetate-mediated cell survival and tumor growth. PMID: 27539851
11. Loss of ACSS2 expression is associated with with gastric cancer. PMID: 26381042
12. Study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. PMID: 25584894
13. Observations suggest that ACSS2 is expressed to a significant extent in particular tumor types, including triple-negative breast cancers. PMID: 25525877
14. Study shows that ACSS2 is upregulated in the human orthotopic tumor and primary human tumors, as well as a murine glioma model; the tumors do not oxidize [U-(13)C]glutamine. In vivo oxidation of [1,2-(13)C]acetate was validated in brain tumor patients and was correlated with expression of acetyl-CoA synthetase enzyme 2, ACSS2. PMID: 25525878
15. During hypoxia, ACSS2 modulates interactions of the acetylase/coactivator CBP with the stress-responsive transcription factor, HIF-2. These interactions include acetylation of HIF-2 by CBP as well as stable HIF-2/CBP complex formation, both of which are required for maximal HIF-2 signaling. Thus, ACSS2 links changes in metabolism that occur during stress with activation of a selective nuclear signaling pathway. PMID: 25108527
16. Ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated acyl-CoA synthetase short-chain family member 2 in 20 healthy individuals. PMID: 20353815
17. Because the activity of a bacterial ortholog of AceCS2, called ACS, is controlled via deacetylation by a bacterial sirtuin protein, our observation highlights the conservation of a metabolic regulatory pathway from bacteria to humans PMID: 16788062
18. The patterns of (18)F-FDG and (11)C-acetate uptake seemed to complement each other in both human HCC and HCC cell lines. PMID: 19617323
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亞細胞定位：

Cytoplasm, cytosol.
蛋白家族：

ATP-dependent AMP-binding enzyme family
數據庫鏈接：

HGNC: 15814

OMIM: 605832

KEGG: hsa:55902

STRING: 9606.ENSP00000253382

UniGene: Hs.517034

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