ACSL6 Antibody

文獻引用 (1) 說明書

中文名稱：

ACSL6兔多克隆抗體
貨號：

CSB-PA892139LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: ACSL6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 78, 81, 75, 77, 80, 70 kDa
Observed band size: 78 kDa
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ACSL6 Polyclonal antibody
Uniprot No.：

Q9UKU0
基因名：

ACSL6
別名：

Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 6) (LACS 6), ACSL6, ACS2 FACL6 KIAA0837 LACS5
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Long-chain-fatty-acid--CoA ligase 6 protein (214-484aa)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ACSL6 Antibody (CSB-PA892139LA01HU)，的標記方式是Non-conjugated。對于ACSL6 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA892139LB01HU	ACSL6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892139LC01HU	ACSL6 Antibody, FITC conjugated
Biotin	CSB-PA892139LD01HU	ACSL6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

p38 mediated ACSL4 phosphorylation drives stress-induced esophageal squamous cell carcinoma growth through Src myristoylation Q Yuan, Y Shi, J Wang, Y Xie, X Li, J Zhao,Nature Communications,2025

產品評價

靶點詳情

功能：

Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
基因功能參考文獻：
1. ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation PMID: 27647415
2. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked PMID: 22205969
3. The alternative fatty acid Gate-domain motifs are essential determinants for the activity of the human ACSL6 isoforms, which appear to act as homodimeric enzyme as well as in complex with other spliced forms. PMID: 20429931
4. The t(5;12)(q23-31;p13)translocation with ETV6-ACSL6 genomic alteration rearrangement in polycythemia vera patients was reported. PMID: 16572202
5. Analyses did not yield convincing evidence for associations of schizophrenia with ACSL6 PMID: 16827919
6. Three ACSL6 spliced variants of a mutually exclusive exon pair are reported, they encode a slightly different short motif which contains a conserved structural domain, the fatty acid Gate domain. PMID: 16834775
7. haplotypes underlying the SPEC2/PDZ-GEF2/ACSL6 region are associated with schizophrenia PMID: 17030554
8. The acyl-coenzyme A synthetase long-chain family member 6 (ACSL6) gene on chromosome 5q31 was associated with premature ovarian failure and identified disease-susceptibility haplotypes. PMID: 18555221
9. ACSL6 is highly associated with schizophrenia and several haplotypes in this haploblock have about twofold to 10-fold increase in the affected subjects in Han Chinese. PMID: 18718982
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相關疾病：

A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.
亞細胞定位：

Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
蛋白家族：

ATP-dependent AMP-binding enzyme family
組織特異性：

Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
數據庫鏈接：

HGNC: 16496

OMIM: 604443

KEGG: hsa:23305

STRING: 9606.ENSP00000296869

UniGene: Hs.14945

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