ACOT8 Antibody

中文名稱：

ACOT8兔多克隆抗體
貨號：

CSB-PA001170LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA001170LA01HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ACOT8 Polyclonal antibody
Uniprot No.：

O14734
基因名：

ACOT8
別名：

ACOT8 antibody; ACTEIII antibody; PTE1 antibody; Acyl-coenzyme A thioesterase 8 antibody; Acyl-CoA thioesterase 8 antibody; EC 3.1.2.1 antibody; EC 3.1.2.11 antibody; EC 3.1.2.2 antibody; EC 3.1.2.3 antibody; EC 3.1.2.5 antibody; Choloyl-coenzyme A thioesterase antibody; EC 3.1.2.27 antibody; HIV-Nef-associated acyl-CoA thioesterase antibody; Peroxisomal acyl-CoA thioesterase 2 antibody; PTE-2 antibody; Peroxisomal acyl-coenzyme A thioester hydrolase 1 antibody; PTE-1 antibody; Peroxisomal long-chain acyl-CoA thioesterase 1 antibody; Thioesterase II antibody; hACTE-III antibody; hACTEIII antibody; hTE antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Acyl-coenzyme A thioesterase 8 protein (1-200AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ACOT8 Antibody (CSB-PA001170LA01HU)，的標記方式是Non-conjugated。對于ACOT8 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001170LB01HU	ACOT8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001170LC01HU	ACOT8 Antibody, FITC conjugated
Biotin	CSB-PA001170LD01HU	ACOT8 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.; (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression.
基因功能參考文獻：
1. In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro. PMID: 24788990
2. Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. PMID: 23540296
3. ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids PMID: 16141203
4. SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription. PMID: 16335799
5. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. PMID: 17624024
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亞細胞定位：

Peroxisome matrix.
蛋白家族：

C/M/P thioester hydrolase family
組織特異性：

Detected in a T-cell line (at protein level). Ubiquitous.
數據庫鏈接：

HGNC: 15919

OMIM: 608123

KEGG: hsa:10005

STRING: 9606.ENSP00000217455

UniGene: Hs.444776

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