ACAP1 Antibody
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中文名稱：ACAP1兔多克隆抗體
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貨號：CSB-PA622985EA01HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: ACAP1 antibody at 4µg/ml
Lane 1: Mouse lung tissue
Lane 2: Jurkat whole cell lysate
Lane 3: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 82 kDa
Observed band size: 82 kDa -
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA622985EA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA622985EA01HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) ACAP1 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：ACAP 1 antibody; ACAP1 antibody; ACAP1_HUMAN antibody; Arf GAP with coiled coil ANK repeat and PH domains 1 antibody; Arf GAP with coiled coil; ankyrin repeat; and pleckstrin homology domains 1 antibody; Arf-GAP with coiled-coil; ANK repeat and PH domain-containing protein 1 antibody; ArfGAP with coiled-coil; ankyrin repeat and PH domains 1 antibody; CENT B1 antibody; Centaurin beta 1 antibody; Centaurin-beta-1 antibody; CENTB 1 antibody; Cnt b1 antibody; Cnt-b1 antibody; Cntb1 antibody; KIAA0050 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 protein (1-266AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，ACAP1 Antibody (CSB-PA622985EA01HU)，的標記方式是Non-conjugated。對于ACAP1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
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基因功能參考文獻：
- The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
- ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions. PMID: 25225293
- CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process. PMID: 23317930
- phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding PMID: 22645133
- the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6/ACAP1. PMID: 22188517
- ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. PMID: 15525538
- CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses PMID: 17005562
- Results suggest that two ARF6 downstream molecules, PIP5K and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics. PMID: 17010122
- Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF) 6, is part of a novel clathrin coat complex that is regulated by ARF6 for endocytic recycling in two key physiological settings. PMID: 17664335
- ACAP1 has robust, constitutive Arf6 GAP activity in vivo, with little activity toward Arf1. PMID: 18003747
- Centaurin beta1/KIAA0050, is a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localisation and activity. PMID: 11050434
- Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid dependent, ARF6 preferring GTPase-activating protein. It can regulate cytoskeletal and membrane trafficking events in the cell periphery and may be regulated via a phosphoinositide-binding PH domain. PMID: 11062263
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亞細胞定位：Recycling endosome membrane; Peripheral membrane protein; Cytoplasmic side.
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組織特異性：Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.
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數(shù)據(jù)庫鏈接：
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