ABR Antibody
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中文名稱：ABR兔多克隆抗體
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貨號：CSB-PA622521LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: Mouse brain tissue
All lanes: ABR antibody at 3.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 98, 94, 36, 93 kDa
Observed band size: 98 kDa -
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA622521LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ABR Polyclonal antibody
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Uniprot No.：
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基因名：ABR
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別名：abr antibody; ABR_HUMAN antibody; Active BCR related antibody; Active BCR related gene antibody; Active breakpoint cluster region related protein antibody; Active breakpoint cluster region-related protein antibody; MDB antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Active breakpoint cluster region-related protein (797-859AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，ABR Antibody (CSB-PA622521LA01HU)，的標記方式是Non-conjugated。對于ABR Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF-1 directed motility and phagocytosis through the modulation of RAC1 activity.
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基因功能參考文獻：
- ABR depletion leads to G2/M accumulation in human embryonic stem cells. Centrosome dynamics and mitotic fidelity are compromised upon ABR depletion. When mitosis progresses without ABR, human embryonic stem cells show a high incidence of aneuploidy. PMID: 28579391
- During vestibular morphogenesis, Abr and Bcr play complementary roles. Small Rho-related GTPases like Abr and Bcr are important for balance and motor coordination. PMID: 11921339
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亞細胞定位：Cell projection, dendritic spine. Cell projection, axon. Cell junction, synapse.
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組織特異性：Highly enriched in the brain. Much weaker expression in heart, lung and muscle.
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數據庫鏈接：
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