ABI2 Antibody

說(shuō)明書

中文名稱：

ABI2兔多克隆抗體
貨號(hào)：

CSB-PA001102LA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA001102LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001102LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA001102LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) ABI2 Polyclonal antibody
Uniprot No.：

Q9NYB9
基因名：

ABI2
別名：

Abelson interactor 2 antibody; ABI 2 antibody; Abi-2 antibody; ABI2 antibody; ABI2_HUMAN antibody; ABI2B antibody; Abl binding protein 3 antibody; Abl interacting protein 1 (SH3 containing protein) antibody; Abl interactor 2 antibody; Abl interactor protein 2b antibody; Abl-binding protein 3 antibody; AblBP3 antibody; AIP 1 antibody; Arg binding protein 1 antibody; Arg protein tyrosine kinase binding protein antibody; Arg-binding protein 1 antibody; ArgBP1 antibody; ARGBPIA antibody; ArgBPIB antibody; OTTHUMP00000163783 antibody; OTTHUMP00000163784 antibody; OTTHUMP00000206182 antibody; OTTHUMP00000206183 antibody; OTTHUMP00000206184 antibody; OTTHUMP00000206185 antibody; SSH3BP2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Abl interactor 2 protein (164-452AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，ABI2 Antibody (CSB-PA001102LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ABI2 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA001102LB01HU	ABI2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001102LC01HU	ABI2 Antibody, FITC conjugated
Biotin	CSB-PA001102LD01HU	ABI2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells.
基因功能參考文獻(xiàn)：
1. TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade PMID: 27932314
2. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia. PMID: 22304832
3. Abi-2 may have a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression PMID: 16488906
4. disruption of the interaction between Bcr-Abl and Abi1 by mutations either in Bcr-Abl or Abi1 not only abolished tyrosine phosphorylation of Abi1 and membrane translocation of Abi1/WAVE2 PMID: 17389688
5. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2 PMID: 18632609
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亞細(xì)胞定位：

Cytoplasm. Nucleus.; [Isoform 1]: Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Cell junction, adherens junction.
蛋白家族：

ABI family
組織特異性：

Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 24011

OMIM: 606442

KEGG: hsa:10152

UniGene: Hs.471156

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