ABAT Antibody
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中文名稱：ABAT兔多克隆抗體
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貨號：CSB-PA001032ESR1HU
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規格：￥440
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圖片：
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Western blot
All lanes: 4-aminobutyrate aminotransferase, mitochondrial antibody at 10μg/ml
Lane 1: Rat liver tissue
Lane 2: Mouse pancreatic tissue
Lane 3: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa -
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001032ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA001032ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ABAT Polyclonal antibody
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Uniprot No.：
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基因名：ABAT
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別名：(S) 3 amino 2 methylpropionate transaminase antibody; (S)-3-amino-2-methylpropionate transaminase antibody; 4 aminobutyrate aminotransferase antibody; 4 aminobutyrate aminotransferase; mitochondrial antibody; 4-aminobutyrate aminotransferase antibody; ABAT antibody; FLJ17813 antibody; FLJ30272 antibody; GABA aminotransferase antibody; GABA AT antibody; GABA T antibody; GABA transaminase antibody; GABA transferase antibody; GABA-AT antibody; GABA-T antibody; GABAT antibody; GABT_HUMAN antibody; Gamma amino N butyrate transaminase antibody; Gamma-amino-N-butyrate transaminase antibody; hCG1984265 antibody; L AIBAT antibody; L-AIBAT antibody; LAIBAT antibody; mitochondrial antibody; NPD009 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse, Rat
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免疫原：Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial protein (29-300AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
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基因功能參考文獻：
- This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance. PMID: 25771305
- A-to-G transition at nucleotide 754 of the human ABAT gene identified in lymphoblast cDNA (c.754A>G) results in substitution of an invariant arginine at amino acid 220 by lysine (p.Arg220Lys). This point mutation results in destabilization of the binding of pyridoxal-5'-phosphate to GABA-transaminase (required for transamination of GABA to succinic semialdehyde) and thus results in GABA-transaminase deficiency. PMID: 25485164
- Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders. PMID: 22225676
- direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control in gastro esophageal reflux disease PMID: 21552517
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20659789
- excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report] PMID: 20052547
- Marked differences in platelet uptake of GABA and activity of catabolic enzyme GABA-T between patients with generalized and localization-related epileptic syndromes. May indicate an impairment in function of brain GABAergic systems. PMID: 12694932
- results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT PMID: 15528998
- lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP at the active site PMID: 15650327
- Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A and ABAT. PMID: 15830322
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相關疾?。?/div>GABA transaminase deficiency (GABATD)亞細胞定位：Mitochondrion matrix.蛋白家族：Class-III pyridoxal-phosphate-dependent aminotransferase family組織特異性：Liver > pancreas > brain > kidney > heart > placenta.數據庫鏈接：
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