A4GALT Antibody

說明書

中文名稱：

A4GALT兔多克隆抗體
貨號(hào)：

CSB-PA868276ESR1HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA868276ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA868276ESR1HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) A4GALT Polyclonal antibody
Uniprot No.：

Q9NPC4
基因名：

A4GALT
別名：

4 N acetylglucosaminyltransferase antibody; 4-galactosyltransferase antibody; 4-N-acetylglucosaminyltransferase antibody; A14GALT antibody; A4GALT antibody; A4GALT1 antibody; A4GAT_HUMAN antibody; Alpha 1 4 galactosyltransferase antibody; Alpha 1 4 N acetylglucosaminyltransferase antibody; Alpha-1 antibody; Alpha4Gal T1 antibody; Alpha4Gal-T1 antibody; CD77 synthase antibody; Gb3 synthase antibody; Gb3S antibody; Globotriaosylceramide synthase antibody; Lactosylceramide 4 alpha galactosyltransferase antibody; Lactosylceramide 4-alpha-galactosyltransferase antibody; P blood group (P one antigen) antibody; P(k) antigen synthase antibody; P1 antibody; P1/Pk synthase antibody; PK antibody; UDP galactose beta D galactosyl beta1 R 4 alpha D galactosyltransferase antibody; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Lactosylceramide 4-alpha-galactosyltransferase protein (244-353AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes. Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P.; (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.
基因功能參考文獻(xiàn)：
1. The differential binding of transcription factor early growth response 1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression. PMID: 29399809
2. A4GALT SNPs spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system PMID: 29709005
3. Study reports a novel mutation in the A4GALT gene that was responsible for a p phenotype in a Chinese individual. PMID: 27612185
4. amino acid residue at position 211 of Gb3/CD77 synthase is critical for specificity and activity of the enzyme involved in formation of P(k), P1 and NOR antigens. Altogether, this approach affords a new insight into the mechanism of action of the human Gb3/CD77 synthase. PMID: 27538840
5. This is the first direct biochemical evidence that Gb3/CD77 synthase is able to synthesize two different glycosphingolipid antigens: P(k) and P1, and when p.Q211E substitution is present, the NOR antigen is also synthesized. PMID: 26773500
6. Mutation in the A4GALT gene is associated with rare p phenotype in P1Pk blood group system. PMID: 25863098
7. The results of this investigation demonstrate a consistent association of A4GALT SNPs rs2143918 and rs5751348 with the P1/P2 phenotypes and suggest that SNP rs5751348 may lead to allelic variations in A4GALT gene expression PMID: 25041587
8. these data elucidate a new explanation underlying the p phenotype, implicating the deleted regions of A4GALT as crucial for P1 and P(k) synthesis, possibly due to loss of binding sites for erythroid transcription factors. PMID: 24417201
9. P1-decorated PSGL-1/mIgG2b bound with high avidity to both Stx1 and Stx2, and as such constitutes a potential therapeutic inhibitor of these toxins. PMID: 24082034
10. several P1PK-null alleles were identified. PMID: 23927681
11. Results suggest that the C631G mutation alters the acceptor specificity of Gb3/CD77 synthase, rendering it able to catalyze synthesis of the Gal(alpha1-4)Gal and Gal(alpha1-4)GalNAc moieties. PMID: 22965229
12. Increased globotriaosylceramide levels are detected in a transgenic mouse expressing human alpha1,4-galactosyltransferase in a mouse model for treating Fabry disease. PMID: 20961863
13. 2 Taiwanese individuals with p phenotype were homozygous for a & 428. No expression of P(k) & no enzyme activity were observed in cells transfected with the mutant construct. PMID: 21092013
14. Total urinary protein isoforms of globotriaosylceramide were used to identify Fabry disease in women. PMID: 21186071
15. Data showed that GRINA-C was associated with Gb3 synthase, and may demonstrate a new type of posttranscriptional regulation of glycosyltransferases. PMID: 20837469
16. of A4GALT mRNA in cultured human bone marrow cells revealed novel transcripts containing only the noncoding exon 1 and a sequence (here termed exon 2a) from intron 1. PMID: 20971946
17. We established by quantitative real-time PCR that both fresh colonic epithelial sections and HCT-8 cells express Gb3 synthase mRNA and the alternate Shiga toxin receptor globotetraosylceramide. PMID: 20732996
18. expression in megakaryoblastic leukemia cells PMID: 11782470
19. The P blood group phenotype is due to several disctint nonfunctional alleles of A4GALT without any predominant allele. PMID: 11896312
20. results strongly suggested that P1 synthase is identical to Gb3/CD77 synthase PMID: 12888565
21. Data show that a novel A4GALT missense mutation causes the p phenotype in Amish individuals. PMID: 18067504
22. the transcriptional regulation of the Gb3S gene by Sp1 might affect the verotoxin sensitivity of endothelial cell and Hemolytic uremic syndrome progression. PMID: 18757779
23. P(k) expression strongly influences susceptibility to HIV-1 infection, which implicates P(k) as a new endogenous cell-surface factor that may provide protection against HIV-1 infection. PMID: 19139081
24. These data show that globotriaosylceramide (Gb3) content, which is regulated by the expression of Gb3 synthase, determines the sensitivity of HeLa cells toward Shiga toxin. PMID: 19470247
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亞細(xì)胞定位：

Golgi apparatus membrane; Single-pass type II membrane protein.
蛋白家族：

Glycosyltransferase 32 family
組織特異性：

Ubiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
數(shù)據(jù)庫鏈接：

HGNC: 18149

OMIM: 111400

KEGG: hsa:53947

STRING: 9606.ENSP00000249005

UniGene: Hs.105956

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