NFKBIB Monoclonal Antibody

說明書

中文名稱：

NFKBIB鼠單克隆抗體
貨號：

CSB-MA869384
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded Human Lung Carcinoma using IκB β(Mouse mAb diluted at 1:200.

Immunohistochemical analysis of paraffin-embedded Human Kidney Tissue using IκB βMouse mAb diluted at 1:200.
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品描述：

CUSABIO貨號：CSB-MA869384 NFKBIB單克隆抗體是針對核因子κB抑制蛋白β（IκBβ）研發的高特異性科研試劑，該靶點作為IκB家族關鍵成員，通過調控NF-κB信號通路在炎癥反應、免疫應答及細胞增殖中發揮重要作用，是腫瘤發生與免疫性疾病機制研究的重要分子標記物。本產品采用雜交瘤技術制備，經嚴格驗證可特異性識別人類、小鼠及大鼠種屬的NFKBIB蛋白，適用于ELISA酶聯免疫吸附實驗與IHC免疫組織化學技術，為研究者提供穩定的抗原-抗體結合性能。在基礎科研領域，該抗體可廣泛應用于體外培養細胞中NF-κB信號通路的動態監測、炎癥相關疾病模型的分子機制解析，以及腫瘤微環境中蛋白互作網絡的實驗研究。其卓越的種屬兼容性使其成為跨物種比較研究的理想工具，特別適用于神經退行性疾病、自身免疫疾病及癌癥生物學等領域的蛋白表達水平分析，為探索NFKBIB在病理生理過程中的調控機制提供可靠檢測方案。
Uniprot No.：

Q15653
基因名：

NFKBIB
別名：

I kappa B beta antibody; I-kappa-B-beta antibody; IkappaBbeta antibody; IKB beta antibody; IkB-B antibody; IkB-beta antibody; IKBB antibody; IKBB_HUMAN antibody; IkBbeta antibody; NF kappa BIB antibody; NF-kappa-B inhibitor beta antibody; NF-kappa-BIB antibody; Nfkbib antibody; Thyroid receptor interacting protein 9 antibody; Thyroid receptor-interacting protein 9 antibody; TR interacting protein 9 antibody; TR-interacting protein 9 antibody; TRIP-9 antibody; TRIP9 antibody
宿主：

Mouse
反應種屬：

Human,Mouse,Rat
免疫原：

Recombinant Protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
純化方式：

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
克隆號：

24G3
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
基因功能參考文獻：
1. The subcellular distributions of IkappaB and NFkappaB are indicative of carcinogenesis. Inhibition of XPO1 results in intranuclear retention of IkappaB, which inhibits NFkappaB and thereby provides a novel mechanism for drug therapy in sarcoma. This effect can be further enhanced in relatively selinexor-resistant sarcoma cell lines by pretreatment with the proteasome inhibitor carfilzomib. PMID: 28314790
2. data suggest that miRNA-4776 modulates Influenza A virus production in infected cells through NFKBIB expression, possibly through the modulation of NF-kappaB. PMID: 28448456
3. our data establish the importance of a novel tumor suppressive IKBB gene in abrogating angiogenesis in NPC via the NF-kappaB signalling pathway. PMID: 26227166
4. NFKBIBrs3136641TT single nucleotide polymorphism was associated with a significantly decreased risk of developing wheezing. PMID: 25326706
5. IkappaBbeta may be a novel target for transcription factors of the HMG-box SRY/Sox family and imply a potential role for NF-kappaB/IkappaBbeta in spermatogenesis PMID: 12475944
6. VEGF increased Mn-superoxide dismutase promoter activity, an effect that was dependent on a second intronic NF-kappaB consensus motif. PMID: 15308628
7. data indicate that inhibition of NFkappa-B activity by the hepatitis C virus core protein might be related to its physical interaction with and interrupted nuclear localization of IKKbeta PMID: 15919917
8. None of the NFKBIB SNPs are associated with pneumococcal susceptibility. PMID: 17463416
9. increased I-kappaBbeta expression reversed NF-kappaB activation in cancer cells, compensating for the loss of I-kappaBalpha via TGase 2 polymerization. PMID: 18950638
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

NF-kappa-B inhibitor family
組織特異性：

Expressed in all tissues examined.
數據庫鏈接：

HGNC: 7798

OMIM: 604495

KEGG: hsa:4793

STRING: 9606.ENSP00000312988

UniGene: Hs.9731

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