KRT16 Monoclonal Antibody
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中文名稱：KRT16鼠單克隆抗體
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貨號：CSB-MA000213
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規(guī)格：￥1090
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圖片：
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IHC staining of human gullet cancer tissue, diluted at 1:200.
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其他：
產品詳情
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產品描述：KRT16單克隆抗體（CUSABIO貨號：CSB-MA000213）是針對角蛋白16靶點研發(fā)的高特異性科研試劑，該蛋白作為中間纖維的重要組成成分，在細胞骨架構建、表皮組織分化和增殖調控中發(fā)揮關鍵作用，其表達異常與多種皮膚角化疾病相關。本產品通過重組人源KRT16蛋白免疫動物制備，經嚴格驗證適用于人類、小鼠及大鼠多物種模型的ELISA蛋白定量檢測與免疫組化實驗，可精準識別天然及重組形式的KRT16蛋白。在科研領域廣泛應用于皮膚屏障功能研究、上皮細胞分化機制探索、腫瘤微環(huán)境分析等方向，為角質形成細胞動態(tài)觀察、病理模型構建提供可靠工具。該抗體具有批次穩(wěn)定性高、種屬兼容性強等特點，特別適合需要跨物種比較的實驗設計，是研究表皮發(fā)育生物學和皮膚相關疾病分子機制的優(yōu)選試劑。
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Uniprot No.：
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基因名：
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別名：CK 16 antibody; CK-16 antibody; CK16 antibody; Cytokeratin 16 antibody; Cytokeratin-16 antibody; Cytokeratin16 antibody; FNEPPK antibody; Focal non epidermolytic palmoplantar keratoderma antibody; K 16 antibody; K16 antibody; K1C16_HUMAN antibody; K1CP antibody; Keratin 1 type I antibody; Keratin 16 antibody; Keratin antibody; Keratin type I cytoskeletal 16 antibody; Keratin-16 antibody; Keratin16 antibody; KRT 16 antibody; Krt16 antibody; KRT16A antibody; NEPPK antibody; PC1 antibody; type I cytoskeletal 16 antibody
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宿主：Mouse
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic Peptide
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免疫原種屬：H, M, R
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標記方式：Non-conjugated
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抗體亞型：IgG
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克隆號：5C1
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:100-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
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基因功能參考文獻：
- Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
- results suggest a conditional regulation of KRT16 gene by ATF4 that may be inhibited in normal cells, but engaged during cancer progression. Potential roles of KRT16, FAM129A and HKDC1 genes upregulation in adaptive stress responses and pathologies are discussed PMID: 29420561
- inflammatory cytokines promoted Nrf2 nuclear translocation in psoriatic epidermis, which led to elevated expression of K6, K16, and K17, thus promoting keratinocyte proliferation and contributing to the pathogenesis of psoriasis. PMID: 28576737
- The wider spectrum of KRT16 mutations suggests that changes in codons 125, 127, and 132 are most commonly responsible for PC-1 and that proline substitution mutations at codons 127 or 128 may produce more severe disease PMID: 24357266
- analysis of a new p.Leu421Pro (c.1262T>C) mutation in the highly conserved helix termination motif of K16 in a large Spanish family that may have a role in pachyonychia congenita PMID: 24118415
- Keratin 16 regulates innate immunity in response to epidermal barrier breach. PMID: 24218583
- Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
- Patients with p.Asn125Asp and p.Arg127Pro mutations in KRT16 exhibited more severe disease than patients carrying p.Asn125Ser and p.Arg127Cys mutations in terms of age of onset of symptoms, extent of nail involvement, and impact on daily quality of life. PMID: 21160496
- Data suggest that an immune response to trichohyalin and K16 may have a role in the pathogenesis of the enigmatic disorder. PMID: 20722389
- coinheritance of mutations in KRT16 and filaggrin may aggravate the pachyonychia congenita phenotype PMID: 19785597
- disease-associated keratin 16 expression is induced by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun PMID: 12954631
- K16 expression is observed in non-lesional psoriatic skin and may serve as a marker of preclinical psoriasis. PMID: 15239676
- ERK2-mediated C-terminal serine phosphorylation of p300 was a key event in the regulation of EGF-induced keratin 16 expression. PMID: 17623675
- DPPIV-expression and enzyme activity, Ki-67 antigen and K16 are significantly upregulated in the centre and inner margin of the psoriatic lesion compared to clinically uninvolved skin and the healthy volunteers skin. PMID: 18496701
- Antikeratin 16 autoAbs are involved in psoriasis, by exaggerating the innate immune response of keratinocytes. PMID: 18557933
- Infection by HPV stimulates the expression of K16 PMID: 19515043
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相關疾病：Pachyonychia congenita 1 (PC1); Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1)
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蛋白家族：Intermediate filament family
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組織特異性：Expressed in the corneal epithelium (at protein level).
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數據庫鏈接：
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