GAP43 Monoclonal Antibody

說明書

中文名稱：

GAP43鼠單克隆抗體
貨號：

CSB-MA080173
規格：

￥1090
圖片：
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using GAP-43 Monoclonal Antibody.

Western blot analysis of 1) Hela, 2) 293T, 3) Mouse Brain Tissue, 4) Rat Brain Tissue using GAP-43 Monoclonal Antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

GAP43單克隆抗體（CUSABIO貨號：CSB-MA080173）是一款針對生長相關蛋白43（GAP-43）的高特異性科研試劑，適用于人類、小鼠及大鼠樣本的檢測需求。GAP-43作為神經系統中高度保守的磷酸化蛋白，廣泛參與軸突生長、突觸可塑性及神經損傷修復等關鍵生理過程，是研究神經發育與再生機制的重要分子標記物。本產品經嚴格驗證可支持ELISA、Western Blot（WB）和免疫組化（IHC）三大實驗平臺，能夠精準識別目標蛋白的天然構象，為神經科學領域的蛋白定位、表達量分析及功能研究提供可靠工具。在神經退行性疾病模型、腦損傷修復機制探索或體外神經元培養實驗中，研究人員可通過該抗體實現對GAP-43動態表達的可視化追蹤與定量檢測，特別適用于探究神經突觸重塑、軸突導向等分子通路的調控機制。其跨物種反應性設計可滿足多模型系統的實驗對照需求，為神經再生研究、藥物靶點篩選及基礎醫學研究提供高效解決方案。
Uniprot No.：

P17677
基因名：

GAP43
別名：

Axonal membrane protein GAP 43 antibody; Axonal membrane protein GAP-43 antibody; B 50 antibody; Calmodulin binding protein P 57 antibody; F1 antibody; GAP 43 antibody; GAP43 antibody; Growth Associated Protein 43 antibody; Growth-associated protein 43 antibody; Nerve Growth Related Peptide antibody; Nerve growth related peptide GAP43 antibody; NEUM_HUMAN antibody; Neural phosphoprotein B 50 antibody; Neural phosphoprotein B-50 antibody; Neuromodulin antibody; Neuron growth associated protein 43 antibody; PP46 antibody; Protein F1 antibody; QtrA-11580 antibody; QtrA-13071 antibody
宿主：

Mouse
反應種屬：

Human,Mouse,Rat
免疫原：

Recombinant Protein
免疫原種屬：

Human, Mouse, Rat
標記方式：

Non-conjugated
抗體亞型：

IgG
克隆號：

14C1
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:50-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
基因功能參考文獻：
1. We found an increased expression of Nestin and GAP43 (growth associated protein 43) in treated cells. In conclusion, Periodontal ligament mesenchymal stem cells (hPDLSCs) treated with Moringin and Cannabidiol showed an improved survival capacity and neuronal differentiation potential PMID: 30096889
2. The expression pattern of the regeneration-associated protein GAP-43 suggested a lower regenerative capacity in nigral dopaminergic neurons of Parkinson disease patients. PMID: 26748453
3. Findings show high level of both YKL-40 and GAP-43 in CSF of older women with suicidal ideation which suggest that a disrupted synaptic glial functioning and inflammation may be related to the aetiology of suicidal ideation in older adults. PMID: 28211584
4. associations of neuromodulin and neurogranin to Alzheimer's disease PMID: 27604409
5. Copy-number variations are enriched for GAP43 and other neurodevelopmental genes in children with developmental coordination disorder. PMID: 27489308
6. Downregulation of GAP43 promotes gliomas. PMID: 27495233
7. The peripheral neuropathies lead to an initial increase in GAP-43 gene expression as a potential mechanism of regeneration, which is not sustained in neuropathies of long duration. PMID: 26071889
8. Results show that PKC-dependent phosphorylation of GAP43 plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses. PMID: 25755278
9. increased expression of TH and GAP43 might be a molecular mechanism for left atrial myoelectricity remodeling of aging atrial fibrillation patients, which might be potential therapeutic targets of atrial fibrillation. PMID: 24301786
10. GAP43 is seemingly a highly sensitive marker for peripheral nerve sheath tumors PMID: 23887302
11. The results showed that the decreased GAP-43 levels induced by glutamate could be partially reversed by the presence of NRG-1beta PMID: 23524246
12. Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43 PMID: 23396970
13. immunostaning for GAP-43 was relatively similar in ganglionic versus aganglionic colon. PMID: 23153097
14. Impaired regeneration of intra-epidermal C fibers in the early stages of type 2 diabetes mellitus, as indicated by GAP-43 expression, might be a marker of incipient diabetic neuropathy. PMID: 22209024
15. The results of this study supported to the hypothesis of multiple rare mutations in schizophrenia, and it provides genetic clues that indicate the involvement of GAP-43 in this disorder. PMID: 22138049
16. Through MEK/ERK pathway, S1P stimulates GAP43 transcription with increased binding of C/EBPbeta to the 5'-promoter PMID: 21769916
17. Results demonstrate that APT-2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution. PMID: 21152083
18. Results indicate that there is no strong and direct interaction between POP and GAP43 at physiological conditions. PMID: 20869470
19. Around 1 month post lesion, degeneration at the cochlear nuclei progressively disappeared and a relevant GAP-43 expression was found. PMID: 19593683
20. chemical analysis of fatty acylated species in GAP43 PMID: 12105219
21. In the dermis, there were fewer GAP-43 nerve fibers than PGP 9.5 fibers, whereas in the epidermis the numbers were equal. Only some Merkel cells and Meissner corpuscles were GAP-43-immunoreactive. PMID: 12704705
22. Data show that GAP43 acts as an osmosensory protein that augments internal calcium in response to hypotonicity. PMID: 12805215
23. Schizophrenia had significant decreases in GAP-43 immunoreactivity in the hilus (p<0.05, paired t-test) and inner molecular layer (p<0.05, paired t-test) but not in the outer molecular layer. In the same tissues. PMID: 15694236
24. Growth-associated protein 43, a marker of neural outgrowth and regeneration, is expressed in endometriosis-associated nerve fibers but not in existing peritoneal nerves. PMID: 17412328
25. HuD plays a role in the post-transcriptional control of GAP-43 mRNA PMID: 17577668
26. Data show that functional cooperation between TrkA and p75(NTR) accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities. PMID: 17619016
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亞細胞定位：

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, axon. Cytoplasm.
蛋白家族：

Neuromodulin family
數據庫鏈接：

HGNC: 4140

OMIM: 162060

KEGG: hsa:2596

STRING: 9606.ENSP00000377372

UniGene: Hs.134974

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