Rat transforming growth factor α,TGF-α ELISA Kit
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中文名稱:大鼠轉化生長因子α(TGF-α)酶聯免疫試劑盒
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貨號:CSB-E07289r
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規格:96T/48T
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價格:¥3900/¥2500
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其他:
產品詳情
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產品描述:大鼠轉化生長因子α(TGF-α)酶聯免疫試劑盒(CSB-E07289r)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的TGFA含量。TGFA即轉化生長因子α,是表皮生長因子家族成員。它可與表皮生長因子受體結合,激活下游信號通路,參與細胞的增殖、分化、遷移等過程。其異常表達與腫瘤等疾病的發生發展密切相關,是藥物研發的潛在靶點。試劑盒檢測范圍為7.8 pg/ml-500pg/ml,特別適用于動物模型中的創傷修復機制探究、腫瘤微環境研究或藥理學實驗中生物標志物動態監測。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:Tgfa ELISA Kit; Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha ELISA Kit; TGF-alpha ELISA Kit; EGF-like TGF ELISA Kit; ETGF ELISA Kit; TGF type 1)] ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Rattus norvegicus (Rat)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:7.8 pg/ml-500pg/ml
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靈敏度:1.95 pg/ml
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Signal Transduction
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測定原理:quantitative
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測定方法:Sandwich
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線性度:
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數據處理:
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貨期:3-5 working days
相關產品
靶點詳情
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功能:TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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基因功能參考文獻:
- 5-HT stimulates DNA synthesis and proliferation in primary cultures of adult rat hepatocytes by acting via autocrine secretion of TGF-alpha induced by the serotonin 5-HT2B receptor/Gq/PLC/Ca2+ pathway. PMID: 26804134
- Lipopolysaccharide exposure led to a suppression of both HDAC1 and HDAC2 expression and activity, induced TGFa expression, and disrupted alveolar morphology. PMID: 24595367
- results support the hypothesis that FSH stimulates granulosa cell proliferation via theca TGFalpha secretion PMID: 12021046
- A novel mechanism for mitogenic signaling via pro-transforming growth factor alpha within hepatocyte nuclei. PMID: 12029622
- TGF-alpha exerts a neuroprotective action against NMDA toxicity, in which Erk1/2 activation plays a key role PMID: 12771152
- TGF-alpha, laminin, and fibronectin are required for ovary follicle development and maturation PMID: 14656002
- TGFalpha plays an autocrine role in LH dependent development and function of Leydig cells. PMID: 15353178
- study adds TGFalpha to the list of dysregulated cytokines present in degrading cartilage in osteoarthritis PMID: 17968906
- mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
- TGF-alpha has the ability to suppress anoikis of intestinal epithelial cells, at least in part, by reverting the loss of c-Src activity and Bcl-X(L) expression induced by detachment from the ECM. PMID: 11487584
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亞細胞定位:[Transforming growth factor alpha]: Secreted, extracellular space.; [Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein.
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數據庫鏈接:
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