Rat Corticosterone,CORT ELISA Kit
-
中文名稱：大鼠皮質(zhì)酮(CORT)酶聯(lián)免疫試劑盒
-
貨號(hào)：CSB-E07014r
-
規(guī)格：96T/48T
-
價(jià)格：￥3900/￥2500
-
其他：
產(chǎn)品詳情
-
產(chǎn)品描述：大鼠皮質(zhì)酮/腎上腺酮(CORT)酶聯(lián)免疫試劑盒（CSB-E07014r）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CORT含量。CORT即皮質(zhì)酮，是一種重要的糖皮質(zhì)激素。它參與機(jī)體應(yīng)激反應(yīng)與代謝調(diào)節(jié)等生理過程。研究機(jī)制上，主要通過與細(xì)胞內(nèi)糖皮質(zhì)激素受體結(jié)合，調(diào)控相關(guān)基因表達(dá)，影響細(xì)胞功能，在神經(jīng)、內(nèi)分泌等多系統(tǒng)中發(fā)揮關(guān)鍵作用。試劑盒檢測范圍為0.2 ng/mL-40 ng/mL，支持科研人員開展神經(jīng)內(nèi)分泌機(jī)制研究、慢性應(yīng)激模型評(píng)估、代謝綜合征相關(guān)實(shí)驗(yàn)及藥物干預(yù)效果驗(yàn)證等領(lǐng)域的探索，為行為學(xué)實(shí)驗(yàn)、神經(jīng)藥理學(xué)研究和激素調(diào)控機(jī)制探索提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
-
別名：N/A
-
縮寫：CORT
-
種屬：Rattus norvegicus (Rat)
-
樣本類型：serum, plasma, tissue homogenates
-
檢測范圍：0.2 ng/mL-40 ng/mL
-
靈敏度：0.1 ng/mL
-
反應(yīng)時(shí)間：1-5h
-
樣本體積：50-100ul
-
檢測波長：450 nm
-
研究領(lǐng)域：Signal Transduction
-
測定原理：quantitative
-
測定方法：Competitive
-
精密度：
Intra-assay Precision (Precision within an assay): CV%<15% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<15% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of rat CORT in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 84 Range % 80-91 1:2 Average % 90 Range % 85-95 1:4 Average % 97 Range % 92-103 1:8 Average % 105 Range % 100-112 -
回收率：
The recovery of rat CORT spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 89-99 EDTA plasma (n=4) 92 88-97 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average 40 0.138 0.132 0.135 10 0.239 0.258 0.249 3.2 0.504 0.509 0.507 0.8 0.939 1.009 0.974 0.2 1.419 1.424 1.422 0 2.154 2.159 2.157 -
數(shù)據(jù)處理：
-
貨期：3-5 working days
引用文獻(xiàn)
- Effects of restraint stress and orthodontic treatment on physical and psychological states in rats Y Cheng, H Nie, J Qian, J Lu, Y Li, H Li,Journal of the World Federation of Orthodontists,2024
- Aging induced Hematological, Anthropometrical, Biochemical, and Reproductive Changes in Male Rats KH Mohamed,Zagazig Veterinary Journal,2024
- The effect of late-life environmental enrichment on stress and anxiety: the role of sex and age-related differences in coping with aversive stimuli M Balietti,Heliyon,2024
- Environmental enrichment and the combined interventions of EE and metformin enhance hippocampal neuron survival and hippocampal-dependent memory in type 2 diabetic rats under stress through the BDNF-TrkB signaling pathways TR Ismail,Biomedicine & pharmacotherapy,2024
- Ketamine causes poor maternal care in rats with postpartum depression and leads to few behavioral and neurochemical alterations on male offspring J Zaccarelli-Magalh?es,Behavioural brain research,2023
- Increase of circulating cfDNA by chronic training or overtraining in human and rat and its possible mechanisms LJ Yin,Science & Sports,2023
- Association analysis of gut microbiota-metabolites-neuroendocrine changes in male rats acute exposure to simulated altitude of 5500 m J Wang,Scientific reports,2023
- Can Resveratrol Influence the Activity of 11β-Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study J Novak,Pharmaceuticals,2023
- Paradoxical Anxiety Level Reduction in Animal Chronic Stress: A Unique Role of Hippocampus Neurobiology Vadim Tseilikman,International Journal of Molecular Sciences,2022
- Circ_0000181 regulates miR-667-5p/NLRC4 axis to promote pyroptosis progression in diabetic nephropathy Y Li,Scientific reports,2022
- The extent of involvement of ouabain, hippocampal expression of Na+/K+-ATPase, and corticosterone/melatonin receptors ratio in modifying stress-induced behavior differs according to the stressor in context S Abdelmissih,Brazilian journal of medical and biological research,2022
- Total Saikosaponins Attenuates Depression-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Rats by Regulating the PI3K/AKT/NF-κB?… Z Zhou,Evidence-Based Complementary and Alternative Medicine,2022
- The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety V Tseilikman,International journal of molecular sciences,2022
- Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway Xiwen Geng,Oxidative Medicine and Cellular Longevity,2021
- Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine YK Mahmoud,Biology,2021
- PET neuroimaging reveals upregulation of dopamine D2 receptor contributes to amygdaloid dysfunction in rat acute restraint stress model Z Yan,Biochemical and Biophysical Research Communications,2021
- Norepinephrine in the dentate gyrus is involved in spatial learning and memory alteration induced by chronic restraint stress in aged rats FX Wang,Neuroreport,2020
- Effect of Light-Dark Cycle Misalignment on the Hypothalamic-Pituitary-Gonadal Axis, Testicular Oxidative Stress, and Expression of Clock Genes in Adult Male Rats A Moustafa,International journal of endocrinology,2020
- Changes in nitric oxide, carbon monoxide, hydrogen sulfide and male reproductive hormones in response to chronic restraint stress in rats A Moustafa,Free Radical Biology and Medicine,2020
- Swim therapy-induced tissue specific metabolic responses in male rats A Moustafa,Life Sciences,2020
- MODULATION OF DEPRESSION-LIKE BEHAVIOR BY A COMBINATION WITH VITAMIN D3 AND 17Β-ESTRADIOL IN MIDDLE-AGED OVARIECTOMIZED RATS SUBJECTED TO CHRONIC MILD STRESS V Mironova,Opera Medica et Physiologica,2020
- The Involvement of Notch1 Signaling Pathway in Mid-aged Female Rats under Chronic Restraint Stress J Shen,Neuroscience Letters,2020
- Saponin extract of Baihe-Zhimu Tang ameliorates depression in chronic mild stress rats D Jia,Journal of Functional Foods,2020
- Hyperfunction of the stress response system and novelty┸\induced hyperactivity correlate with enhanced cocaine┸\induced conditioned place preference in NCAM … B K盲hler,Addict Biol,2020
- Increased Oxidative Damage Contributes to Mitochondrial Dysfunction in Muscle of Depressed Rats Induced by Chronic Mild Stress Probably Mediated by SIRT3 … Q Xiao,ANIMAL AND HUMAN PHYSIOLOGY,2020
- Vitamin D3 attenuates anxiety-like behavior in long-term ovariectomized rats with unpredictable mild stress BARANENKO D,BIOCELL,2019
- Synergic action of Vitamin D3 and 17β-estradiol on behavioral impairments induced by unpredictable mild stress in the adult ovariectomized female rats Fedotova J, et al,Biorxiv,2019
- Mechanisms of Stress-Induced Spermatogenesis Impairment in Male Rats Following Unpredictable Chronic Mild Stress (uCMS) Zou P, et al,International Journal of Molecular Sciences,2019
- Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone Song J, et al,Journal of Translational Medicine,2019
- Acute restraint stress alters food-foraging behavior in rats: Taking the easier Way while suffered Tu BX,Brain Research Bulletin,2019
- Chronic paradoxical sleep deprivation-induced depression Ma W, et al,Life Sciences,2019
- Changes in Secretory Activity of Adrenal Zona Fasciculata Cells in Pubertal Rats Exposed to Low Doses of DDT in Different Periods of Ontogeny Yaglova NV, et al,Bulletin of experimental biology and medicine,2018
- Social defeat stress before pregnancy induces depressive-like behaviours and cognitive deficits in adult male offspring: correlation with neurobiological changes Wei S.et al,BMC Neuroscience,2018
- Transplantation of bone marrow mesenchymal stem cells reduces GluR1 expression in the hippocampus and amygdala and affects secretion of stress-related hormones in rats with spinal cord injuries: a potential anti-chronic stress mechanism Jia-Jia Sun.et al,INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2018
- Perfluorooctane sulfonate (PFOS) can alter the hypothalamic?pituitary?adrenal (HPA) axis activity by modifying CRF1 and glucocorticoid receptors R. Salgado.et al,Toxicology Letters,2018
- Antidepressant-like effect of lipid extract of Channa striatus in postpartum model of depression in rats Abdul Shukkoor MS.et al,Evid Based Complement Alternat Med,2016
- Acupuncture alters pro-inflammatory cytokines in the plasma of maternally separated rat pups Wang Z.et al,Chin J Integr Med. ,2017
- Role of early environmental enrichment on the social dominance tube test at adulthood in the rat Cao WY.et al,Psychopharmacology (Berl).,2017
- Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats Samarghandian S.et al,BMC Complement Altern Med.,2017
- Curcumin reverses the depressive-like behavior and insulin resistance induced by chronic mild stress Shen JD.et al,Metab Brain Dis.,2017
- Exogenous hydrogen sulfide eliminates spatial memory retrieval impairment and hippocampal CA1 LTD enhancement caused by acute stress via promoting glutamate uptake He J.et al,Neuroscience,2017
- THERAPEUTICS FOR THE INDUCTION OF ENDOGENOUS STEROIDOGENESIS AND METHODS ASSOCIATED WITH THEIR IDENTIFICATION Papadopoulos V.et al, U.S. Patent ,2016
- Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress. Luo YW.et al,Neuropharmacology.,2015
- Protective Effects of Carvacrol against Oxidative Stress Induced by Chronic Stress in Rat's Brain, Liver, and Kidney Saeed Samarghandian. et al,Biochemistry Research International,2016
- Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats Gheibi N et al,Basic Clin Neurosci,2015
- Regulation of corticosterone secretion is modified by PFOS exposure at different levels of the hypothalamic-pituitary-adrenal axis in adult male rats Pereiro N et al,Toxicol Lett,2014
- Orcinol glucoside produces antidepressant effects by blocking the behavioural and neuronal deficits caused by chronic stress Ge JF et al,Eur Neuropsychopharmacol,2013
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
-
最新研究進(jìn)展：CORT是一種重要的激素，可以影響多種生理過程，如免疫和應(yīng)激反應(yīng)。最近的研究表明，CORT可以通過影響免疫細(xì)胞的活動(dòng)來調(diào)節(jié)免疫反應(yīng)。例如，在炎癥過程中，CORT可以抑制炎癥介質(zhì)的產(chǎn)生，從而緩解炎癥反應(yīng)。此外，CORT也被認(rèn)為是抑制免疫系統(tǒng)過度激活的重要因素之一。最近的研究還表明，CORT可能在多種神經(jīng)系統(tǒng)疾病中具有治療潛力，例如抑郁癥和焦慮癥等。
Most popular with customers
-
Human Transforming Growth factor β1,TGF-β1 ELISA kit
Detect Range: 23.5 pg/ml-1500 pg/ml
Sensitivity: 5.8 pg/ml
-
-
-
Mouse Tumor necrosis factor α,TNF-α ELISA Kit
Detect Range: 7.8 pg/ml-500 pg/ml
Sensitivity: 1.95 pg/ml
-
-
-
-
