Rabbit cholesteryl ester transfer protein,CETP ELISA Kit

Rabbit cholesteryl ester transfer protein,CETP ELISA Kit

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文獻(xiàn)引用 (1) 說明書下載

中文名稱：

兔子膽固醇酯轉(zhuǎn)移蛋白(CETP)酶聯(lián)免疫試劑盒
貨號：

CSB-E06841Rb
規(guī)格：

96T/48T
價格：

￥4200/￥3000
其他：

CUSABIO Wins 2024 Bioz Rapid Star? Award in the ELISA category

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產(chǎn)品描述：

兔子膽固醇酯轉(zhuǎn)移蛋白(CETP)酶聯(lián)免疫試劑盒（CSB-E06841Rb）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CETP含量。CETP（膽固醇酯轉(zhuǎn)運蛋白）是一種血漿糖蛋白，其功能是促進膽固醇酯從高密度脂蛋白（HDL）轉(zhuǎn)移到低密度脂蛋白（LDL）和極低密度脂蛋白（VLDL），從而影響血脂水平。CETP抑制劑通過抑制CETP活性，增加血清HDL-C水平并降低LDL-C水平，被視為治療血脂異常的潛在方法。試劑盒檢測范圍為1.56 ng/mL-100 ng/mL，科研人員可將其應(yīng)用于高脂血癥模型兔的血清標(biāo)志物分析、脂蛋白代謝通路研究或針對CETP抑制劑的藥效學(xué)評價，可為脂質(zhì)代謝機制研究、動物模型評估及藥物開發(fā)中CETP活性調(diào)控分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
別名：

CETPCholesteryl ester transfer protein ELISA kit; Lipid transfer protein I ELISA kit; Fragment ELISA kit
縮寫：

CETP
Uniprot No.：

P22687
種屬：

Oryctolagus cuniculus (Rabbit)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

1.56 ng/mL-100 ng/mL
靈敏度：

0.39 ng/mL
反應(yīng)時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領(lǐng)域：

Metabolism
測定原理：

quantitative
測定方法：

Competitive

精密度：

線性度：

To assess the linearity of the assay, samples were spiked with high concentrations of rabbit CETP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
	Sample	Serum(n=4)
1:100	Average %	99
	Range %	94-102
1:200	Average %	97
	Range %	94-100
1:400	Average %	83
	Range %	80-86
1:800	Average %	91
	Range %	87-95

回收率：

The recovery of rabbit CETP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

Sample Type	Average % Recovery	Range
Serum (n=5)	100	97-103
EDTA plasma (n=4)	84	81-89

標(biāo)準(zhǔn)曲線：

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ng/ml	OD1	OD2	Average
100	0.082	0.086	0.084
50	0.169	0.178	0.174
25	0.241	0.258	0.250
12.5	0.361	0.378	0.370
6.25	0.582	0.541	0.562
3.12	0.878	0.898	0.888
1.56	1.208	1.231	1.220
0	2.015	2.068	2.042

數(shù)據(jù)處理：

ELISA操作視頻及標(biāo)曲繪制軟件下載
貨期：

3-5 working days

Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Shoucui Gao.et al,Mediators of Inflammation,2017

功能：

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.
亞細(xì)胞定位：

Secreted.
蛋白家族：

BPI/LBP/Plunc superfamily, BPI/LBP family
組織特異性：

Expressed by the liver.
數(shù)據(jù)庫鏈接：

STRING: 9986.ENSOCUP00000011306

UniGene: Ocu.1994

Intra-assay Precision (Precision within an assay): CV%<8%

Three samples of known concentration were tested twenty times on one plate to assess.

Inter-assay Precision (Precision between assays): CV%<10%

Three samples of known concentration were tested in twenty assays to assess.