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中文名稱：小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒
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貨號：CSB-E10787m
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規格：96T/48T
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價格：￥3800/￥2500
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其他：
產品詳情
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產品描述：小鼠β淀粉樣蛋白1-42(Aβ1-42)酶聯免疫試劑盒（CSB-E10787m）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的Aβ1-42含量。Aβ1-42是重要的阿爾茨海默病相關靶點。在患者腦內該蛋白異常聚集形成淀粉樣斑塊，破壞神經細胞功能與結構。研究聚焦其產生、聚集過程及與神經毒性的關聯，旨在通過抑制生成、促進清除等機制來改善病情、研發治療藥物。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于阿爾茨海默病小鼠模型構建、Aβ病理機制研究、藥物干預效果評估等實驗場景，為神經科學領域提供可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：Amyloid beta 42(ABeta 42),amyloid beta peptide 1-42,Aβ1-42,amyloid βpeptide 1-42
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縮寫：Aβ1-42
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：15.6 pg/mL-1000 pg/mL
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靈敏度：3.9 pg/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Neuroscience
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse Aβ1-42 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 92 Range % 88-99 1:2 Average % 95 Range % 85-105 1:4 Average % 96 Range % 90-105 1:8 Average % 93 Range % 86-100 -
回收率：
The recovery of mouse Aβ1-42 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 95 90-100 EDTA plasma (n=4) 93 85-96 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
pg/ml OD1 OD2 Average Corrected 1000 2.490 2.451 2.471 2.337 500 2.049 1.985 2.017 1.883 250 1.357 1.385 1.371 1.237 125 0.866 0.837 0.852 0.718 62.5 0.517 0.524 0.521 0.387 31.2 0.347 0.355 0.351 0.217 15.6 0.244 0.228 0.236 0.102 0 0.135 0.132 0.134 -
數據處理：
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貨期：3-5 working days
引用文獻
- Effects of m6A methylation of MAT2A mRNA regulated by METTL16 on learning and memory, hippocampal synaptic plasticity and Aβ1–42 in 5?×?FAD mice H Chen, F Guo, Y Zhao, W Liu, B Chen,Frontiers in Aging Neuroscience,2025
- A Novel Missense Variant in SORBS2 Is Causative With Familial Alzheimer's Disease Q Wang, S Wang, S Cao, Q Wang, Y Wei,CNS Neuroscience & Therapeutics,2025
- Ultrasound Stimulation Modulates Microglia M1/M2 Polarization and Affects Hippocampal Proteomic Changes in a Mouse Model of Alzheimer's Disease X Lu, W Sun, L Leng, Y Yang, S Gong,Immunity, Inflammation and Disease,2024
- Inhibition of Amyloid-β (Aβ)-Induced Cognitive Impairment and Neuroinflammation in CHI3L1 Knockout Mice through Downregulation of ERK-PTX3 Pathway HJ Ham,International journal of molecular sciences,2024
- Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer's disease Y Guo,In vitro cellular & developmental biology. Animal,2023
- Bioengineered microglia-targeted exosomes facilitate Aβ clearance via enhancing activity of microglial lysosome for promoting cognitive recovery in Alzheimer's disease Y Hao,Biomaterials Advances,2023
- Yuanzhi Powder Facilitated the Aβ Clearance in App/Ps1 Mice: Target to the Drainage of Glymphatic System and Meningeal Lymphatic Vessels J Li,Available at SSRN 4528275,2023
- Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer's disease W Li,BMC medicine,2023
- The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice A Anand,European journal of pharmacology,2023
- TNIP2 Inhibits Amyloidogenesis by Regulating the 3'UTR of BACE1 L Wang,Neuroscience letters,2023
- TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: an in vitro study L Chen,Neuroscience letters,2023
- Protective Effect of Biobran/MGN-3 against Sporadic Alzheimer's Disease Mouse Model: Possible Role of Oxidative Stress and Apoptotic Pathways MH Ghoneu,Oxidative Medicine and Cellular Longevity,2021
- Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice Qing-Hua Lon,BMC Chinese Medicine,2021
- Astaxanthin Improved the Cognitive Deficits in APP/PS1 Transgenic Mice Via Selective Activation of mTOR C Huang,Journal of Neuroimmune Pharmacology,2020
- Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: Involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis R Hao,Food and Chemical Toxicology,2020
- Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier Wei J, et al,Drug and Chemical Toxicology,2019
- Nanoformulated ellagic acid ameliorates pentylenetetrazol-induced experimental epileptic seizures by modulating oxidative stress, inflammatory cytokines and apoptosis in the brains of male mice El-Missiry M A, et al,Metabolic Brain Disease,2019
- Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice Ham H J, et al,Translational Neurodegeneration,2019
- Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction Xu YJ,Brain Research,2019
- PROTEASOME INHIBITORS Kim, Kyung Bo,/,2019
- MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation Zhu BL, et al,Brain,2019
- K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression Ji Yeon Choi, .et al,Journal of Neuroinflammation,2018
- Knockdown of BACE1 Wenting Zhang.et al,EXP THER MED,2018
- Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer’s Disease: Stereochemistry and Biological Activity Xiao-Long Hu.et al,ACS CHEM NEUROSCI,2018
- Ligustilide ameliorates memory deficiency in APP/PS1 transgenic mice via restoring mitochondrial dysfunction Yi-Jun Xu.et al,/,2018
- The Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer\'s Disease Cai H.et al,Sci Rep,2018
- Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice Haobin Cai.et al,learning and memory,2017
- Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer\'s Disease Kuang X.et al,Front Aging Neurosci,2017
- Role of 3-Acetyl-11-Keto-Beta-Boswellic Acid in Counteracting LPS-Induced Neuroinflammation via Modulation of miRNA-155 Sayed AS.et al,Mol Neurobiol,2017
- (E)-2-Methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates LPS-Mediated Memory Impairment by Inhibition of STAT3 Pathway Choi JY.et al,Neuromolecular Med.,2017
- KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer’s disease models Lee DY.et al,Oncotarget.,2017
- Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice Neuroscience.et al,Neuroscience,2017
- The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice Tian F.et al,PLoS One.,2017
- Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice Kanchan Bharti.et al,Biometals.,2016
- Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice Leilei Yu.et al,Journal of Functional Foods,2017
- Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice. Bharti K.et al,Biometals.,2016
- Antidiabetic drugs restore abnormal transport of amyloid-ß across the blood-brain barrier and memory impairment in db/db mice Chen F. et al,Neuropharmacology,2015
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■ 常見問題解答
Q:
Hi I would like to ask the following for the item Mouse amyloid beta peptide 1-40 ELISA kits:
1. How may test samples can be performed in 1 kit, is it possible to use the kit for 1 96-well plate
A:
Thanks for your inquiry. This is a 96T sandwich ELISA kit (double-antibody). For a 96T sandwich ELISA kit we suggest you run duplicates for the standard. In this way you can test 80 samples. We also suggest you run duplicates for the sample, and in this way you can test 40 samples. You can decide how many kits you need according to the number of your samples. If you run a pre-test, the number of samples you can detect in one kit will be less.
靶點詳情
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最新研究進展：Aβ1-42是β淀粉樣蛋白（Aβ）家族的一員，它是阿爾茨海默病（AD）病理學的主要成分。最近的研究表明，Aβ1-42的積聚是導致AD的主要因素之一。已經發現許多抗Aβ1-42藥物，如免疫療法和β-淀粉樣蛋白藥物，這些藥物能夠清除Aβ1-42，并恢復AD患者的認知能力。此外，一些研究還發現，Aβ1-42可能是癲癇的重要病理因素，這為癲癇治療提供了新的思路。
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