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中文名稱：人信號肽,CUB和EGF樣結構域蛋白1(SCUBE1)酶聯免疫試劑盒
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貨號：CSB-E15005h
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規格：96T/48T
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價格：￥3600/￥2500
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其他：
產品詳情
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產品描述：人信號肽,CUB和EGF樣結構域蛋白1(SCUBE1)酶聯免疫試劑盒（CSB-E15005h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SCUBE1含量。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于基礎科研中探索SCUBE1在疾病模型中的表達動態、信號通路關聯性分析，或作為分子標志物在細胞實驗、動物模型及臨床前樣本中的定量評估，為研究血管生成、組織修復及病理機制提供可靠工具。滿足分子生物學及轉化醫學研究的精準檢測需求。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
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別名：SCUB1_HUMAN ELISA Kit; SCUBE 1 ELISA Kit; SCUBE1 ELISA Kit; Signal peptide, CUB and EGF-like domain-containing protein 1 ELISA Kit; Signal peptide, CUB domain, EGF like 1 ELISA Kit
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縮寫：SCUBE1
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Uniprot No.：
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種屬：Homo sapiens (Human)
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樣本類型：serum, plasma, tissue homogenates
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檢測范圍：0.625 ng/mL-40 ng/mL
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靈敏度：0.156 ng/mL
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反應時間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領域：Cardiovascular
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of human SCUBE1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:5 Average % 89 Range % 82-94 1:10 Average % 96 Range % 91-105 1:20 Average % 99 Range % 95-108 1:40 Average % 94 Range % 86-102 -
回收率：
The recovery of human SCUBE1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 106 99-110 EDTA plasma (n=4) 92 84-96 -
標準曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 40 2.670 2.592 2.631 2.502 20 2.271 2.173 2.222 2.093 10 1.631 1.615 1.623 1.494 5 0.940 0.925 0.933 0.804 2.5 0.512 0.502 0.507 0.378 1.25 0.357 0.347 0.352 0.223 0.625 0.226 0.219 0.223 0.094 0 0.130 0.127 0.129 -
數據處理：
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貨期：3-5 working days
引用文獻
- The assessment of the relationship between the development of cardiovascular diseases and SCUBE-1 level in individuals exposed to loud noise H Fedai, K Toprak, M Cetin, AN Elmas, V Tosun,Medicine,2024
- Biomarkers In Prediction of Acute Mesenteric Ischaemia: a prospective multicentre study (BIPAMI study): a study protocol K Tamme,BMJ open,2024
- SCUBE1 promotes pulmonary artery smooth muscle cell proliferation and migration in acute pulmonary embolism by modulating BMP7 L Jia,PeerJ,2024
- The diagnostic potential of plasma SCUBE‐1 concentration for pulmonary embolism: A pilot study L Xiao,The clinical respiratory journal,2023
- CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma J Zhao,Journal of translational medicine,2022
- Can serum SCUBE1 levels be useful in the diagnosis of bladder cancer? A MENTE?E,Journal of Experimental and Clinical Medicine,2022
- Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery T ?zkara,CARDIOVASCULAR JOURNAL OF AFRICA,2021
- Diagnostic value of signal peptide-Complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 on serum and tissue samples in non-small cell lung cancer Selcuk Gurz.et al,/,2018
- The Diagnostic Value of Scube1 in Patients Presenting to the Emergency Department Due to Angina Pectoris Aynur SAHIN.et al,/,2018
- The predictive value of signal peptide-CUB-EGF domain-containing protein1 (SCUBE1) in terms of the duration of peripheral ischemia and exposure to reperfusion Ozgur Sogut.et al,Biomed Res Int.,2016
- The Diagnostic Value of Plasma SCUBE1, a Novel Biomarker of Platelet Activation, in Testicular Torsion: A Randomized, Controlled, Experimental Study Turedi S.et al,Urology,2015
- Increased serum concentrations of signal peptide-Cub-Egf domain-containing protein-1 in patients with aneurysmal subarachnoid hemorrhage. Ding YS.et al,Clin Chim Acta.,2016
- The diagnostic role of signal peptide-C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein 1 in non-ST-elevation acute coronary syndrome. Sonmez E.et al,Am J Emerg Med.,2015
- The role of hypoxia at primary dysmenorrhea, utilizing a novel hypoxia marker--SCUBE1. Tekin YB.et al,J Pediatr Adolesc Gynecol.,2015
- Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer Topcu TO.et al,Tohoku J Exp Med.,2015
- Role of signal peptide-Cub-Egf domain-containing protein-1 in serum as a predictive biomarker of outcome after severe traumatic brain injury Chen QH.et al,Clin Chim Acta.,2016
- Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study Bilir B.et al,Eur Rev Med Pharmacol Sci.,2016
- The diagnostic value of SCUBE1 levels in acute ischemic stroke Mücahit Günaydin et al,Türk Biyokimya Dergisi,2014
- Signal peptide-UB-GF domain-containing protein 1 (SCUBE1) levels in patients with overt and subclinical hyperthyroidism: effects of treatment Erem C. et al,Clin Endocrinol (Oxf),2015
- Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level /,Clinical Biochemistry,2012
- The diagnostic and prognostic significance of SCUBE1 levels in Crimean-Congo hemorrhagic fever Mentese A et al,Int J Infect Dis.,2013
產品評價
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靶點詳情
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功能：Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology.
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基因功能參考文獻：
- The results of this pioneering study indicate that SCUBE protein family appears to have a probable role in the pathogenesis and angiogenesis development in psoriasis and SCUBE 1 and 3 may be novel markers of angiogenesis in psoriasis. PMID: 28238185
- enhanced SCUBE1 concentrations are correlated with increasing severity and poor outcomes of aneurysmal subarachnoid hemorrhage patients, indicating SCUBE1 might have the potential to identify aneurysmal subarachnoid hemorrhage patients at risk of poor prognosis PMID: 27265525
- Increased serum SCUBE1 concentrations have close relation to increasing severity and poor prognosis of intracerebral hemorrhage PMID: 27496080
- SCUBE1 might be a novel prognostic biomarker after traumatic brain injury PMID: 26940951
- describe novel mechanisms in targeting S1 to the plasma membrane and demonstrate that N-glycans are required for S1 functions during primitive haematopoiesis in zebrafish. PMID: 26699903
- SCUBE1 may indicate hypercoagulability in patients with BC and thus help identify patients at greater risk of thrombosisSCUBE1 may indicate hypercoagulability in patients with breast cancer and thus help identify patients at greater risk of thrombosis PMID: 26438214
- SCUBE1 levels are a new biomarker that can be used in the differential diagnosis and monitoring of patients hospitalized with suspected CCHF. PMID: 23632301
- Primary prostatic cancer-associated fibroblasts (CAFs) were isolated and the expression of CAF markers, Dlk1 and SCUBE1 transcripts were characterised. PMID: 23136397
- SCUBE 1 levels in patients with gastric cancer were found higher compared to healthy subjects. PMID: 23220851
- SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event. PMID: 22874483
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亞細胞定位：Secreted. Cell membrane; Peripheral membrane protein.
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組織特異性：Detected in endothelial cells. Highly expressed in platelets. Stored in platelet alpha granules, and transferred to the cell surface upon activation and aggregation. A smaller form, probably produced by limited proteolysis, after being released from the s
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