Human Neurotrophin 4,NT-4 ELISA KIT
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中文名稱:人神經營養因子4(NT-4)酶聯免疫試劑盒
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貨號:CSB-E04689h
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規格:96T/48T
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價格:¥3200/¥2500
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其他:
產品詳情
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產品描述:人神經營養因子4(NT-4)酶聯免疫試劑盒(CSB-E04689h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的NTF4含量。人神經營養因子4(NT-4)是一種神經營養因子,與外周感覺交感神經元密切相關,參與神經元生存和維持。其作用機制涉及與TrkB和p75NTR受體結合,調節神經元生長、發育和功能。NT-4在胰腺癌神經浸潤(PNI)中扮演重要角色,可能通過促進癌細胞與神經的交互作用,導致PNI發生。試劑盒檢測范圍為31.25 pg/ml-2000 pg/ml,科研人員可將其應用于神經發育機制研究、藥物干預效果評估或疾病模型中的NT - 4動態變化分析,為探索神經系統相關疾病的分子機制提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:GLC10 ELISA Kit; GLC1O ELISA Kit; Neurotrophic factor 4 ELISA Kit; Neurotrophic factor 5 ELISA Kit; Neurotrophin 4 ELISA Kit; Neurotrophin 4/5 ELISA Kit; Neurotrophin 5 (neurotrophin 4/5) ELISA Kit; Neurotrophin 5 ELISA Kit; Neurotrophin-4 ELISA Kit; Neurotrophin-5 ELISA Kit; Neutrophic factor 4 ELISA Kit; Neutrophic factor 5 ELISA Kit; NT 4 ELISA Kit; NT 4/5 ELISA Kit; NT 5 ELISA Kit; NT-4 ELISA Kit; NT-5 ELISA Kit; NT4 ELISA Kit; NT4/5 ELISA Kit; NT4P ELISA Kit; NT5 ELISA Kit; NTF4 ELISA Kit; NTF4_HUMAN ELISA Kit; NTF5 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:31.25 pg/ml-2000 pg/ml.
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靈敏度:7.8 pg/ml.
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Neuroscience
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測定原理:quantitative
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測定方法:Sandwich
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精密度:
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線性度:
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回收率:
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標準曲線:
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數據處理:
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貨期:3-5 working days
相關產品
靶點詳情
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功能:Target-derived survival factor for peripheral sensory sympathetic neurons.
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基因功能參考文獻:
- Elevated intra-amniotic levels of docosahexaenoic acid and arachidonic acid in the mid-trimester are correlated with increased NT4 concentrations. PMID: 24607879
- The NTF4 variants p.Gly157Ala and p.Ala182Val have been shown to be functional mutations, occurring in 2 of a total of 720 Chinese primary open-angle glaucoma patients. PMID: 22815630
- NT-4/5 expression is associated with atrophy of the brain-parenchymal fraction measured by magnetic resonance imaging methods in patients with relapsing-remitting multiple sclerosis. PMID: 22036954
- Suggest that a dysregulated TrkB/NT4/5 axis may contribute to several of the pathological lesions associated with pulmonary fibrosis, including type 2 alveolar cell hyperplasia and the proliferation of fibroblasts. PMID: 21330466
- neurotrophin 4 contributes to breast cancer cell survival and can serve as prospective target to inhibit tumor growth PMID: 21350004
- In vitro follicular assembly is significantly increased in fetal ovaries cultured with NT-4. PMID: 20447632
- Identification of a single mutation in our study suggests that NTF4 mutations are a rare cause of primary open-angle glaucoma (0.6%, 95%CI 0.02%-3.16%) in Chinese people. PMID: 20806036
- present data indicate a lack of involvement of variations in NTF4, VAV2, and VAV3 with glaucoma pathogenesis in an Indian population. PMID: 20463313
- Expression of human NTF4 was unchanged during gestation in the developping ovary. PMID: 20175187
- No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. PMID: 20215012
- A mechanism to understand the defect associated with variant BDNF and provide a framework two ligands for BDNF and NT-4. PMID: 15987945
- Re-expression of the p75NTR appears to partially reverse de-differentiation of prostate cancer cells by up-regulating the expression of CRABPI for localized sequestration of retinoids. PMID: 16316409
- Results revealed the expression of NT-4/5 mainly in oocytes and, in a minority of samples, also in the granulosa cells (GCs). PMID: 16648150
- These novel data demonstrate that neurotrophins influence ASM [Ca(2+)](i) and force regulation and suggest a potential role for neurotrophins in airway diseases PMID: 16648236
- Neurotrophin 4/5 plays a role in the proliferation and differentiation of periodontal ligament cells. PMID: 18980528
- Data show that the levels of NT-4/5 levels are significantly higher in bipolar disorder patients than in controlsNT-4/5. immunocontent alterations in bipolar disorder. PMID: 19081579
- NTF4 mutations impair neurotrophin-4 signaling in patients with primary open-angle glaucoma and lead to decreased activation of TrkB PMID: 19765683
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相關疾病:Glaucoma 1, open angle, O (GLC1O)
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亞細胞定位:Secreted.
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蛋白家族:NGF-beta family
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組織特異性:Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
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數據庫鏈接:
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